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Mashup Score: 18Definitions and use of tumor bulk in phase 3 lymphoma trials: a comprehensive literature review - 2 day(s) ago
Key PointsIn phase 3 lymphoma randomized trials, definitions of bulk and its use in the design vary significantly across and within disease subtypes.Of 87
Source: ashpublications.orgCategories: General Medicine NewsTweet
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Mashup Score: 13Maximum tumor diameter is associated with relapse risk in limited-stage Hodgkin lymphoma: an international study - 2 day(s) ago
Key PointsIncreasing MTD is strongly associated with increased risk of relapse in limited-stage HL.MTD and treatment with chemotherapy alone are independen
Source: ashpublications.orgCategories: General Medicine NewsTweet-
MTD and treatment with chemotherapy alone are independent risk factors; patients with both risk factors had suboptimal event-free survival. https://t.co/DS8pXeGDB7 #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/lry8dRdyAK
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Mashup Score: 17Comparison of progression risk of monoclonal gammopathy of undetermined significance by method of detection - 4 month(s) ago
Key PointsThe progression risk of patients with MGUS diagnosed with MGUS during population screening vs routine clinical care is similar.The MGUS detection
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The MGUS detection method did not impact the MGUS risk model (monoclonal protein isotype, size, and abnormal FLC ratio) predictive value. https://t.co/Nxyq2CpP1N #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/ypl4aXG1Ii
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Mashup Score: 24Follicular lymphoma comprises germinal center–like and memory-like molecular subtypes with prognostic significance - 5 month(s) ago
Key PointsRNA sequencing identified MEM- and GC-like FL subtypes associated with specific cell of origin, mutational profiles and clinical outcomes.IHC can
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
IHC can be used routinely to identify patients with MEM-like FL with adverse PFS who can benefit from treatments other than R-chemotherapy. https://t.co/6IiVhHvA7L #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/4MgrHjBnAU
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Mashup Score: 9Transcriptomic and proteomic differences in BTK-WT and BTK-mutated CLL and their changes during therapy with pirtobrutinib - 8 month(s) ago
Key PointsOmics analyses demonstrated that BTK-mutated CLL has augmented proliferative signaling when compared with BTK-WT CLL.Proliferation-promoting path
Source: ashpublications.orgCategories: General Medicine News, Onc News and JournalsTweet-
Proliferation-promoting pathways are suppressed after the first cycle of treatment with pirtobrutinib in BTK-WT and -mutated CLL. https://t.co/vVbJzw14Px #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/z3XGNbuTzX
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Mashup Score: 19ATM germ line pathogenic variants affect outcomes in children with ataxia-telangiectasia and hematological malignancies - 8 month(s) ago
Key PointsThe major cause of death in patients with ataxia-telangiectasia and hematological malignancies is treatment-related toxicity.The germ line ATM pa
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The germ line ATM pathogenic variant functional class is a robust outcome predictor, which can be applied to therapy stratification. https://t.co/bB7PX0hgqg #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/vPuk9PGb6d
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Mashup Score: 65Randomized study of induction with bendamustine-rituximab ± bortezomib and maintenance with rituximab ± lenalidomide for MCL - 8 month(s) ago
Key PointsMCL BR-based induction and R-based maintenance gave 88% overall response rate, 91% measurable residual disease–negative and median PFS 6.9 years.
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
MCL BR-based induction and R-based maintenance gave 88% overall response rate, 91% measurable residual disease–negative and median PFS 6.9 years. https://t.co/6IoByE93IE #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/qJGlHM40x0
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Mashup Score: 18Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma - 8 month(s) ago
Key PointsRapid targeted genotyping of CSF prospectively detected hallmark single-nucleotide variants in 42% of patients with new CNS tumors.Integrating th
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
Integrating this approach in a CLIA environment accelerated times to diagnosis and treatment for patients with newly diagnosed CNS lymphoma. https://t.co/YhBlpit7wH #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/FAD1o5VG0h
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Mashup Score: 14Risk of transformation by frontline management in follicular and marginal zone lymphomas: a US population–based analysis - 9 month(s) ago
Key PointsThe 10-year HGT cumulative incidence rate was 4.87% in FL and 2.95% in MZL.Upfront treatment reduced the risk of transformation in FL but not in
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The 10-year HGT cumulative incidence rate was 4.87% in FL and 2.95% in MZL. https://t.co/amVSgfpSpc #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/rLCEez9BoL
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Mashup Score: 14Risk of transformation by frontline management in follicular and marginal zone lymphomas: a US population–based analysis - 9 month(s) ago
Key PointsThe 10-year HGT cumulative incidence rate was 4.87% in FL and 2.95% in MZL.Upfront treatment reduced the risk of transformation in FL but not in
Source: ashpublications.orgCategories: General Medicine News, Oncologists1Tweet-
The 10-year HGT cumulative incidence rate was 4.87% in FL and 2.95% in MZL. https://t.co/amVSgfpSpc #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/rLCEez9BoL
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Of 87 trials, 32 analyzed bulk as a prognostic marker in their study design with only 5 demonstrating association with survival outcomes. https://t.co/0TOMRJnxDN #lymphoidneoplasia #clinicaltrialsandobservations https://t.co/dx2cM1vXC8