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Mashup Score: 33Secretogranin 2 binds LILRB4 resulting in immunosuppression - 15 day(s) ago
Nature Immunology – Here the authors identify the granin hormone SCG2 as a ligand for the inhibitory receptor LILRB4. They show that SCG2 released from tumors can suppress antitumor immune…
Source: www.nature.comCategories: General Medicine NewsTweet
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Mashup Score: 74De novo-designed pMHC binders facilitate T cell–mediated cytotoxicity toward cancer cells - 16 day(s) ago
The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patient material remains complex. We present a rapid de …
Source: www.science.orgCategories: General Medicine NewsTweet-
An AI platform now enables rapid design of protein binders that reprogram #ImmuneCells to target #Cancer, potentially accelerating personalized immunotherapy development from years to weeks. @sciencemagazine https://t.co/5Bh4Yoc27o https://t.co/jyISvWWNnI
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Mashup Score: 9Immune cells have a metabolic backup plan for accessing their anti-cancer playbook - 12 month(s) ago
Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.
Source: medicalxpress.comCategories: General Medicine News, General HCPsTweet-
#ImmuneCells have a metabolic backup plan for accessing their anti-#cancer playbook @VAInstitute @JExpMed https://t.co/ipLDNAHcFs
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Mashup Score: 9
Lymph nodes are the canaries in the coal mine of our immune system—firing into gear at the first indication of illness, then sending immune cells where they’re needed in the body to fight infection …
Source: phys.orgCategories: General Medicine News, General HCPsTweet-
RT @physorg_com: Nanoparticles 'hitchhike' on #immuneCells to catch #cancer metastasis early @USC https://t.co/SyqIooxbJi
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A hormone binding to the LILRB4 receptor on #ImmuneCells suppresses their tumor-fighting function, enabling #Cancer to evade detection and suggesting new targets for immunotherapy and inflammatory disease treatment. @UTSWNews @natimmunol https://t.co/Ut2P7V8l8U