Mount Sinai Fuster Heart Hospital, New York, New York, USA Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain ∗Address for correspondence: Dr Valentin Fuster, Mount Sinai Fuster Heart Hospital, One Gustave Levy Place, Box 1030, New York, New York 10029-6500, USA. E-mail: E-mail Address: [email protected] Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain Health Research Institute, Fundación Jiménez Díaz Hospital, Universidad Autónoma de