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Mashup Score: 1Dynamic Post-Transcriptional Events Governing CD8+ T Cell Homeostasis and Effector Function - 4 year(s) ago
Effective T cell responses against infections and tumors require a swift and ample production of cytokines, chemokines, and cytotoxic molecules. The production of these effector molecules relies on rapid changes of gene expression, determined by cell-intrinsic signals and environmental cues. Here, we review our current understanding of gene-specific regulatory networks that define the magnitude…
Source: Trends in ImmunologyCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 3Stem, Effector, and Hybrid States of Memory CD8+ T Cells - 5 year(s) ago
CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and, consequently, the mechanism(s) that contribute to memory development. Here, we…
Source: Trends in ImmunologyCategories: General Medicine News, Latest HeadlinesTweet-
Read the Opinion @TrendsImmuno on #Stem, #Effector, and #Hybrid States of #Memory #CD8 #TCells in #Cancer, by Enrico Lugli, Giovanni Galletti, Shannon K. Boi & Ben Youngblood https://t.co/s7uiGCRTm3 #ASHG20 https://t.co/R6s00DWYXl
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Mashup Score: 2Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy - 5 year(s) ago
The full potential of T cell-based immunotherapies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms that can become imprinted to stably reduce the antitumor ability of T cells. Here, we discuss recent insights into memory CD8+ T cell differentiation and exhaustion and the association of these differentiation states with clinical outcomes during immune…
Source: Trends in ImmunologyCategories: General Medicine News, Latest HeadlinesTweet-
Check out the Opinion @TrendsImmuno on Rewriting History: #Epigenetic #Reprogramming of #CD8 #TCell #Differentiation to Enhance #Immunotherapy by Caitlin C. Zebley, Stephen Gottschalk and Ben Youngblood, https://t.co/LUZbJBxNmc #ASHG20 https://t.co/cv7KZGI1Wi
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Mashup Score: 6Volume 20 Issue 4, April 2020 - 5 year(s) ago
Volume 20 Issue 4, April 2020
Source: www.nature.comCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Our April issue, out NOW! Featuring articles on tumour cell-autonomous signalling after #radiotherapy; #CD8 #Tcell states in human cancer; cancer #systemsbiology & #TumourHeterogeneity and evolutionary trade-offs of #cancer. Have a look: https://t.co/gCTpj2jU4s @NatResCancer https://t.co/WmoqYAHIE8
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Mashup Score: 2Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations - 5 year(s) ago
The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell–mediated immunity against intracellular pathogens and tumors. However, whether BATF3 intrinsically
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
New in #TheJI: #CuttingEdge from @Brian_Sheridan_ | novel cell intrinsic role for #Batf3 in regulating #CD8 #Tcell #memory development. https://t.co/WlZZUezT9h #ReadTheJI #immunology @StonyBrookMed https://t.co/TJpMTJX37H
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Mashup Score: 2Cutting Edge: Batf3 Expression by CD8 T Cells Critically Regulates the Development of Memory Populations - 5 year(s) ago
The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell–mediated immunity against intracellular pathogens and tumors. However, whether BATF3 intrinsically
Source: The Journal of ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
New in #TheJI: #CuttingEdge from @Brian_Sheridan_ | novel cell intrinsic role for #Batf3 in regulating #CD8 #Tcell #memory development. https://t.co/WlZZUezT9h #ReadTheJI #immunology @StonyBrookMed https://t.co/TJpMTJX37H
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Mashup Score: 3Issue: Trends in Immunology - 5 year(s) ago
Redefining Memory T Cell SubsetsRod A. Rahimi,Andrew D. LusterIt has become increasingly clear that the terms used to define memory T cell subsets no longer accurately reflect our understanding of memory T cell biology. Here, we discuss the limitations of our current terminology and propose a new approach for defining memory T cell subsets.Full-Text HTMLPDF Flipping the Switch…
Source: www.cell.comCategories: Allergy-Immunology, Latest HeadlinesTweet-
Read August issue @TrendsImmuno! #Cardiac #MastCells, #ILC2 & #ILC3 in #gut, #inflammation & #celldeath, #organoids in #immunoncology, #epigenetics & #tumor #immunotherapy, #Tcell #memory & #CD8 #Tcell #differentiation, #hematopoiesis & #malignancy & more: https://t.co/Dk6F3tgoR2 https://t.co/uCN8DT9ZwO
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Mashup Score: 0Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy - 5 year(s) ago
The full potential of T cell-based immunotherapies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms that can become imprinted to stably reduce the antitumor ability of T cells. Here, we discuss recent insights into memory CD8+ T cell differentiation and exhaustion and the association of these differentiation states with clinical outcomes during immune…
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
New Opinion Featured Article @TrendsImmuno on Rewriting History: #Epigenetic #Reprogramming of #CD8+ #TCell #Differentiation to Enhance #Immunotherapy, by Caitlin C. Zebley, Stephen Gottschalk & Ben Youngblood @StJudeResearch https://t.co/rLIVx70Vje https://t.co/NVFHsswPpX
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Mashup Score: 2Instructing Memory in CD8+ Thymocytes - 5 year(s) ago
T cells can sometimes acquire properties of a memory cell without encountering foreign antigen. Miller et al. now show that development of such ‘memory phenotype’ (MP) CD8+ T cells starts with recognition of self-ligands in the thymus, and finishes in peripheral tissues. These cells respond rapidly during infection, and infiltrate tumors, where they express high amounts of PD-1.
Source: Trends in ImmunologyCategories: Allergy-Immunology, Latest HeadlinesTweet-
Read the Spotlight @TrendsImmuno on Instructing #Memory in #CD8+ #Thymocytes by Katherine Maude Ashby & Kristin Ann Hogquist @hogqu001- special issue on #molecular mechanisms of #Immunity, https://t.co/vIC8e0iKDQ https://t.co/sRCFM2Ldxj
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Mashup Score: 1Stem, Effector, and Hybrid States of Memory CD8+ T Cells - 5 year(s) ago
CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and, consequently, the mechanism(s) that contribute to memory development. Here, we…
Source: Trends in ImmunologyCategories: General Medicine News, Latest HeadlinesTweet-
Read the Opinion @TrendsImmuno on #Stem, #Effector, and #Hybrid States of #Memory #CD8 #TCells in #Cancer, by Enrico Lugli, Giovanni Galletti, Shannon K. Boi & Ben Youngblood #ISSCR2020 https://t.co/zwKPjoeob7 https://t.co/MuwCSbz7iz
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Read the Review @TrendsImmuno on #Dynamic #PostTranscriptional Events Governing #CD8+ #TCell #Homeostasis & #Effector Function by Fiamma Salerno, Martin Turner & Monika C. Wolkers https://t.co/dcn9wubX5c #cellbio2020 https://t.co/nQeI779zFK