• Mashup Score: 4
    Inhibition of CDK4/6 promotes CD8 T-cell memory formation - 4 year(s) ago

    CDK4/6 inhibitors are approved to treat breast cancer and are in trials for other malignancies. We examined CDK4/6 inhibition in mouse and human CD8 T cells during early stages of activation. Mice receiving tumor-specific CD8 T cells treated with CDK4/6 inhibitors displayed increased T cell persistence and immunologic memory. CDK4/6 inhibition upregulated Mxd4, a negative regulator of Myc, in…

    Source: Cancer Discovery
    Categories: Latest Headlines, Oncologists1
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      SCIDirector

      SCI leader Nathanael Gray & colleagues discovered CDK4/6 inhibitor therapy increases the frequency of #CD8 memory precursors and downregulates expression of #MYC target genes, and may augment long-term protective immunity for #cancerpatients. https://t.co/LBqmnzdhnb #CDK4 #CDK6

  • Mashup Score: 0
    CD8+ T cells specific for conserved coronavirus epitopes correlate with milder disease in COVID-19 patients - 4 year(s) ago

    A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill or die, whereas others have only a mild disease course or are asymptomatic. Here we report development of an improved multimeric αβ T cell staining reagent platform, with each maxi-ferritin “spheromer” displaying 12 peptide-MHC complexes. Spheromers stain specific T cells more efficiently than peptide-MHC…

    Source: Science Immunology
    Categories: Healthcare Professionals, Latest Headlines
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      westr

      CD8 #Tcells specific for conserved #coronavirus epitopes correlate with milder disease in #COVID__19 patients https://t.co/IsYoGNY3sD #IMMUNITY: "preferential recruitment of memory #CD8+ T cells to cross-reactive epitopes likely contributes to mild symptoms" in milder disease. https://t.co/nUrodZQcos

  • Mashup Score: 4
    Rewriting History: Epigenetic Reprogramming of CD8+ T Cell Differentiation to Enhance Immunotherapy - 4 year(s) ago

    The full potential of T cell-based immunotherapies remains limited by a variety of T cell extrinsic and intrinsic immunosuppressive mechanisms that can become imprinted to stably reduce the antitumor ability of T cells. Here, we discuss recent insights into memory CD8+ T cell differentiation and exhaustion and the association of these differentiation states with clinical outcomes during immune…

    Source: Trends in Immunology
    Categories: General Medicine News, Latest Headlines
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      CellPressNews

      Read the Opinion @TrendsImmuno by Caitlin C. Zebley, Stephen Gottschalk & Ben Youngblood, Rewriting History: #Epigenetic Reprogramming of #CD8+ #TCell #Differentiation to Enhance #Immunotherapy @CellCellPress #AAI2021 https://t.co/i1Al9nAsgr #immunology

  • Mashup Score: 21
    Current issue: Trends in Immunology - 4 year(s) ago

    Tonsil organoids: peering down the throat of human immunityAnimal studies and explant cultures of human lymphoid tissues do not reliably model human vaccine responses. A remarkable strategy for reassociation of human tonsillar cells in ex vivo culture leads to organoid formation and provides an exciting new tool to probe human humoral immune responses to infection.Full-Text HTMLPDF …

    Source: www.cell.com
    Categories: Allergy-Immunology, Latest Headlines
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    • Profile photo of TrendsImmuno
      TrendsImmuno

      The May issue is out @TrendsImmuno!! #tonsil #organoids, #synovial #macrophages, B-ALL, mesenchymal-immune cells in #adipose tissue, #fasting & immunity, #CD8 #Tcell #metabolism & #immunity, #CRISPR in immunity & #cancer, #RNAdecay & immune #development!! https://t.co/3PClLa3Dji https://t.co/7i48DWHbe6

  • Mashup Score: 0
    The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells - 4 year(s) ago

    Memory T cells (Tmem) rapidly mount Ag-specific responses during pathogen reencounter. However, Tmem also respond to inflammatory cues in the absence of an activating TCR signal, a phenomenon termed bystander activation. Although bystander activation was first described over 20 years ago, the physiological relevance and the consequences of T cell bystander activation have only become more evident…

    Source: The Journal of Immunology
    Categories: Allergy-Immunology, Latest Headlines
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      J_Immunol

      Newest #BriefReview: The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells https://t.co/RFJBssQ4yW #ReadtheJI #immunology #cd8 #tcells https://t.co/WSTIu3P8Fv

  • Mashup Score: 2
    Stem, Effector, and Hybrid States of Memory CD8+ T Cells - 4 year(s) ago

    CD8+ T cell immunological memory of past antigen exposure can confer long-lived protection against infections or tumors. The fact that CD8+ memory T cells can have features of both naïve and effector cells has forced the field to struggle with several conceptual questions about the developmental origin of the cell and, consequently, the mechanism(s) that contribute to memory development. Here, we…

    Source: Trends in Immunology
    Categories: General Medicine News, Latest Headlines
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      CellPressNews

      Read the Opinion @TrendsImmuno on #Stem, #Effector, and #Hybrid States of #Memory #CD8 #TCells in #Cancer, by Enrico Lugli, Giovanni Galletti, Shannon K. Boi & Ben Youngblood https://t.co/6MdBdDJHnl #cellbio2020 https://t.co/VFGVUutk63

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