Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance | Journal of Applied Physiology | American Physiological Society

It has not been established which physiological processes contribute to endurance training-related changes (Δ) in aerobic performance. For example, the relationship between intramuscular metabolic responses at the intensity used during training and improved human functional capacity has not been examined in a longitudinal study. In the present study we hypothesized that improvements in aerobic capacity (V̇o2max) and metabolic control would combine equally to explain enhanced aerobic performance. Twenty-four sedentary males (24 ± 2 yr; 1.81 ± 0.08 m; 76.6 ± 11.3 kg) undertook supervised cycling training (45 min at 70% of pretraining V̇o2max) 4 times/wk for 6 wk. Performance was determined using a 15-min cycling time trial, and muscle biopsies were taken before and after a 10-min cycle at 70% of pretraining V̇o2max to quantify substrate metabolism. Substantial interindividual variability in training-induced adaptations was observed for most parameters, yet “low responders” for ΔV̇o2max w

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