Zhang et al. determined human OAT1 structures in the apo state and bound to probenecid, adefovir, cefazolin, and PAH, revealing a planar ligand-binding mode. Distinctly, the OAT4-DHEAS structure displays a perpendicular ligand-binding mode.
Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an…
tRNA modifications functionally interact with m6A to regulate mRNA decay.
How high stand density and shade regulate cambial activity and wood formation in perennial trees remains unclear. Wei et al. demonstrate that, in Populus, the…
Nahiyera et al. uncover the distinct Sca1pos neutrophils enriched in murine liver under steady-state condition, which increase during pathological conditions. Characterization reveals these cells as…
Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron,…
Surface solar radiation (SSR) refers to the solar shortwave radiation (SWR) that reaches the Earth’s surface, serving as the primary energy source for life on…
Utilizing brain mapping technologies, the Mesoscopic Brain Mapping Consortium reports diverse cell types and their connectivity primarily in mouse and primate brains, providing insights into…
In this issue of Cancer Cell, Zhang et al. report an innovative approach utilizing patients’ blood T cell receptor (TCR) sequences for the early detection…
In this study, Zhao et al. identify Angiopoietin-like 3 (ANGPTL3) as a regulator of hepatic fructose metabolism in metabolic dysfunction-associated steatotic liver disease (MASLD), independent…
Significant progress has been made in recent years in applying large language models and multimodal artificial intelligence to health and medicine, transforming diagnostics, patient interactions,…
