STINGing leukemia stem cells through PSTK inhibition
In this issue of Blood, He et al provide compelling evidence that PSTK inhibition triggers ferroptotic cell death and links ferroptosis to cyclic GMP-AMP s
In this issue of Blood, He et al provide compelling evidence that PSTK inhibition triggers ferroptotic cell death and links ferroptosis to cyclic GMP-AMP s
Key PointsWe developed a neural network–based probabilistic classifier, DLBclass, that assigns each DLBCL to its respective C1-C5 genetic subtype.DLBclass
Key PointsAML-MP and MPAL are biologically distinct despite sharing features of MP.AML-MP and MPAL have differential responses to therapies.
Key Points. PTCy based GVHD prophylaxis benefit extends to adults ≥ 70 years with improved GVHD control and improved immunosuppression-free survival.Overal
Myelodysplastic syndromes/neoplasms (MDS) are a widely heterogenous group of myeloid malignancies characterized by morphologic dysplasia, a defective hemat
Not all patients with higher-risk myelodysplastic syndromes (MDSs) warrant or are suitable for allogeneic stem cell transplantation. Mina and Komrokji disc
Key PointsYoung untreated patients with MCL show 13% prevalence of M-CH at baseline.Large M-CH clones (variant allele frequency ≥ 10%) are associated with
Key PointsAML-MP and MPAL are biologically distinct despite sharing features of MP.AML-MP and MPAL have differential responses to therapies.
Khylia Marshall is a freelance journalist based in Tucson, Arizona. Previous studies have revealed disparities in the prevalence, management, and outcomes of multiple myeloma (MM)…
Key PointsTBL1X plays a multifaceted role in promoting the proliferation and survival of MCL cells.Targeting TBL1X promotes destabilization of cyclin D1 an
Key PointsYoung untreated patients with MCL show 13% prevalence of M-CH at baseline.Large M-CH clones (variant allele frequency ≥ 10%) are associated with