Nature Immunology – In this Resource paper, the authors use MIBI spatial proteomics to map microglial cell states in brains from cognitively normal humans and those with Alzheimer’s disease.
Nature Reviews Cancer – In this Tools of the Trade article, Jess Hebert describes the development and use of Cas12a mice for the unbiased, high-throughput…
Nature Medicine – Using data from six population-scale cohorts involving more than 10 million individuals, a large language model-based aging signature is shown to outperform…
Nature – Study of nearly 1,000 people showed that brain ageing was not linked to infection status, but cognitive decline was.
Nature Medicine – Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct…
Nature Reviews Cancer – In this Journal Club, Halder and Srivastava discuss a study that investigated how activation-induced deaminase (AID)-mediated DNA double-strand breaks lead to…
Nature Reviews Neurology – Approximately half of the people currently with multiple sclerosis (MS) are ≥50 years of age, yet guidelines for management of MS in…
Precision microbiome programming for therapeutic applications is limited by challenges in achieving reproducible colonic colonization. Previously, we created an exclusive niche that we used to…
Nature Metabolism – LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus…
Scientific Reports – Assembly of CCR5 with gp120 inhibits the HIV infectivity specifically in T cells
npj Parkinson’s Disease – Modeling and optimizing deep brain stimulation to enhance gait in Parkinson’s disease: personalized treatment with neurophysiological insights
