Southern Tick-Associated Rash Illness | NEJM
A 65-year-old man presented with 1-day history of a rash with a bull’s-eye appearance on his left hip. One week earlier, he had removed a tick from his hip after doing yard work near the woods by h…
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Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of heart-failure admission among high-risk patients. However, most patients with valvular heart disease, including those undergoing…
Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis | NEJM
Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). In this ongoing phase 3, multicenter, randomize…
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Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis | NEJM
Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). In this ongoing phase 3, multicenter, randomize…
Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a) | NEJM
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Lentiviral Gene Therapy for Severe Leukocyte Adhesion Deficiency Type 1 | NEJM
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Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a) | NEJM
Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepa…
Lepodisiran — A Long-Duration Small Interfering RNA Targeting Lipoprotein(a) | NEJM
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Identification of Hepatic-like EPO as a Cause of Polycythemia | NEJM
Secondary erythrocytosis often results from conditions that cause tissue hypoxia or an improper increase in erythropoietin (EPO) production. EPO, the major regulator of erythropoiesis, has…
Anticoagulation or Antiplatelet Therapy for Device-Detected Atrial Fibrillation | NEJM
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