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Mashup Score: 2
Background. Lung cancer is the leading cause of cancer death for both men and women in the United States. The National Lung Screening Trial (NLST) demonstrated that low-dose computed tomography (LDCT) screening can reduce lung cancer mortality among high-risk indi…
Source: www.researchsquare.comCategories: Latest Headlines, PulmonologyTweet
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Mashup Score: 2Pre-radiotherapy ctDNA liquid biopsy for risk stratification of oligometastatic non-small cell lung cancer - 2 year(s) ago
The optimal treatment for patients with oligometastatic non-small cell lung cancer (NSCLC) remains unclear. Some patients with oligometastatic disease can experience prolonged remission after locally consolidative radiation therapy (RT), while others harbor micrometastatic disease (below current …
Source: www.researchsquare.comCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @aadel_chaudhuri: Preprint related to the abstract for those who are interested: https://t.co/zbft06ogmh
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Mashup Score: 1Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS - 2 year(s) ago
The CD8+ T-cell response is prognostic for survival outcomes in several tumor types. However, whether this extends to tumors in the brain, an organ with barriers to T cell entry, remains unclear. Here, we analyzed immune infiltration in 67 brain metastasis (BrM) and found…
Source: www.researchsquare.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Check out our new preprint on the immune architecture in brain mets and the impact of pre-op SRS. @careyjans @HaydnKissick https://t.co/JkDoYHgQ7y
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Mashup Score: 0Patterns of flavored e-cigarette use among adults vapers in the United States: an online cross-sectional survey of 69,233 participants - 2 year(s) ago
Background. Flavored e-cigarettes remain a controversial topic with regulators planning or already implementing restrictions worldwide. In this study we examined patterns of flavors use in e-cigarettes among a convenience sample of US adult vapers.Methods. Participants…
Source: www.researchsquare.comCategories: Cardiologists, Latest HeadlinesTweet-
"Patterns of flavored e-cigarette use among adults vapers in the United States: an online cross-sectional survey of 69,233 participants" (preprint, currently under review) https://t.co/6sHBk6rYNn
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Mashup Score: 8
Background: Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease (COVID-19) and Long COVID/Post-Acute Sequelae of COVID-19 (PASC), might form a suitable set of foci …
Source: www.researchsquare.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
Where's the peer-reviewed literature on micro clots? This paper was first published in December 2021. Still a preprint, though it has been updated. Thanks if you can point me. https://t.co/xP72fFkW8P
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Mashup Score: 2Statin prevents cancer development in chronic inflammation by blocking interleukin 33 expression - 2 year(s) ago
Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by the environmental causes of chronic inflammation is unknown. Herein, we demonstrate that Toll-like receptor (TLR)3/4-…
Source: www.researchsquare.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Preprint on inflammation-cancer axis via @researchsquare: In preclinical models, statins prevent development of #PancreaticCancer in chronic inflammation by blocking interleukin 33 (IL-33) expression induced via TBK1-IRF3 signaling. https://t.co/oFd65x5d3g
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Mashup Score: 4mRNA-LNP expressing PfCSP and Pfs25, two leading vaccine candidates targeting infection and transmission of Plasmodium falciparum - 2 year(s) ago
Malaria is a deadly disease responsible for between 550,000 and 627,000 deaths annually. There is a pressing need to develop vaccines focused on malaria elimination. The complex lifecycle of Plasmodium falciparum provides opportunities not only to target the infectious sporozoite stag…
Source: www.researchsquare.comCategories: General Medicine News, Latest HeadlinesTweet-
#mRNAvaccines offer one-two punch to combat #malaria https://t.co/jMe1xUzpD6 https://t.co/KDiJUWVgAh
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Mashup Score: 0Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity - 2 year(s) ago
Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. Howev…
Source: www.researchsquare.comCategories: Cardiologists, Latest HeadlinesTweet-
"Nicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity" https://t.co/qm8B8iIoQ4 https://t.co/YUBG0TrGP4
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Mashup Score: 14A novel therapeutic bispecific format based on synthetic orthogonal heterodimers enables T cell activity against Acute Myeloid Leukemia - 3 year(s) ago
Many therapeutic bispecific T-cell engagers (BiTEs) are in clinical trials. A modular and efficient process to create BiTEs would accelerate their development and clinical applicability. In this study, we present the design, production, and functional activity of a novel bispecific format util…
Source: www.researchsquare.comCategories: Hem/Oncs, Latest HeadlinesTweet-
And in case you missed it, a new modular bispecific antibody produced by my grad student, Alan Burke, which is remarkably effective at recognizing leukemic cells. https://t.co/rxUgPaQMjD
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Mashup Score: 18Exploring the depth and breadth of the genomics toolbox during the COVID-19 pandemic: Insights from Aotearoa New Zealand. - 3 year(s) ago
Genomic technologies have become routine in the surveillance and monitoring of the Coronavirus Disease 2019 (COVID-19) pandemic, as evidenced by the millions of SARS-CoV-2 sequences uploaded to the Global Initiative on Sharing Avian Influenza Data (GISAID). Yet the ways in which these technologie…
Source: www.researchsquare.comCategories: Infectious Disease, Latest HeadlinesTweet-
Super excited to share another preprint with you all. This one is on New Zealand's changing use of genomic technologies during the pandemic. Was a privilege and a pleasure to work with @BunceDNA @Jemma_Geoghegan & @Joepdl on this. https://t.co/QDfimwaccN
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Leveraging #socialmedia to increase #Lungcancer #screening #awareness, #knowledge and uptake among high- #Risk #populations (The INSPIRE-Lung Study): #Study #protocol of #design and #methods of a #community-based randomized controlled trial https://t.co/YbgbURv7z7 https://t.co/yKicVQBBCx