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Mashup Score: 87Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Nephrotoxicity: A Position Statement from the American Society of Onco-nephrology - 6 month(s) ago
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer and are now the backbone of therapy for several malignancies. However, ICIs can cause a spectrum of renal immune-related adverse events including acute kidney injury (AKI), most commonly manifesting as acute interstitial nephritis (AIN), though glomerular disease and electrolyte disturbances have also been reported. In this position statement by the American Society of Onco-nephrology (ASON), we summarize the incidence and risk factors for ICI-AKI, pathophysiological mechanisms and clinicopathological features of ICI-AKI.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet
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Mashup Score: 4Looking into the cholesterol crystal ball: is complement the answer? - 7 month(s) ago
Cholesterol crystal embolism (CCE) is a complication of atherosclerosis and can cause microvascular obstruction in multiple organs. Because the consequences may be fatal, and there is no specific treatment, it is crucial to understand the mechanisms and identify treatment strategies. In this issue, Zhao et al., using a mouse model of kidney CCE, demonstrated that inhibition of C5a/C5aR prevented and resolved CCE-induced renal thrombosis and angiopathy. Although these findings must be extended to human condition, they offer hope for management of CCE syndrome.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
RT @ChangUCanSpare: If you haven't figured it out yet, complement will always be at least part of the answer https://t.co/E5NG8r1xLI
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Mashup Score: 10Interference of urinary albumin-to-creatinine ratio measurement by glycosuria: clinical implications when using SGLT-2 inhibitors - 7 month(s) ago
Urinary albumin-to-creatinine ratio (uACR) measured on spot samples provides a convenient method to screen for, diagnose, stage, and monitor chronic kidney disease (CKD),1 and change in albuminuria is proposed as a surrogate outcome for CKD progression in clinical trials.2 Sodium glucose cotransporter-2 (SGLT-2) inhibitors are increasingly used because of important effects on risk of cardiovascular disease and CKD progression.3 Under normoglycemic and modest hyperglycemic conditions, SGLT-2 inhibitors increase urinary glucose excretion to ∼50–80 g/d, and to >100 g/d in people with diabetes and glomerular hyperfiltration.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
@GlassockJ @SabineKaram6 @M_Elraggal @KIReports @CKJsocial This is the data Prof G is alluding to From https://t.co/0lSR1mIhWt - not about efficacy, but the use of albuminuria as a surrogate outcome while Flozinating Pushback: - can be overcome by using Enzymatic, not Jaffe assay - only clinically relevant when terribly high BS? https://t.co/CV8lpQyhqH
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Mashup Score: 5Clonal Monocytosis of Renal Significance - 7 month(s) ago
Clonal monocytosis reflects a preneoplastic or neoplastic sustained increase in the absolute monocyte count in the absence of reactive causes. Causes of clonal monocytosis include clonal cytopenias with monocytosis and acute and chronic myeloid neoplasms. Chronic myelomonocytic leukemia (CMML) is a prototypical myelodysplastic/myeloproliferative overlap neoplasm in adults, characterized by sustained peripheral blood monocytosis. Renal abnormalities, including acute kidney injury (AKI) and chronic kidney disease (CKD), are frequent in patients with CMML and are predictors of worse outcomes.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
RT @VirginiaCabel10: Clonal Monocytosis of Renal Significance - Kidney International https://t.co/yGYqxlZh2l
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Mashup Score: 26In remembrance of Barry Morton Brenner, MD (1937–2024) - 7 month(s) ago
Barry Morton Brenner passed away on August 6, 2024, at the age of 86 years, following an extended illness. His impact on nephrology research and education, and on the Brigham and Women’s Hospital Renal Division, as well as his personal impact on so many, cannot be overstated. He contributed so much to so many areas of kidney basic science and clinical research. His contributions to our understanding of glomerular physiology and hyperfiltration generated insights that were key to providing the only effective therapy we had to slow down the progression of chronic kidney disease for many years.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
Two great articles about Dr. Brenner. Highly recommended to residents/fellows/young faculty so that they appreciate the role of research for kidney disease and its impact in nephrology as the chosen specialty. @CJASN @Kidney_Int https://t.co/qY8IautGdc https://t.co/nLqQujyDx5
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Mashup Score: 4Clonal Monocytosis of Renal Significance - 8 month(s) ago
Clonal monocytosis reflects a preneoplastic or neoplastic sustained increase in the absolute monocyte count in the absence of reactive causes. Causes of clonal monocytosis include clonal cytopenias with monocytosis and acute and chronic myeloid neoplasms. Chronic myelomonocytic leukemia (CMML) is a prototypical myelodysplastic/myeloproliferative overlap neoplasm in adults, characterized by sustained peripheral blood monocytosis. Renal abnormalities, including acute kidney injury (AKI) and chronic kidney disease (CKD), are frequent in patients with CMML and are predictors of worse outcomes.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
RT @VirginiaCabel10: Clonal Monocytosis of Renal Significance - Kidney International https://t.co/yGYqxlZh2l
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Mashup Score: 26The CONVINCE randomized trial found positive effects on quality of life for patients with chronic kidney disease treated with hemodiafiltration - 8 month(s) ago
In the CONVINCE trial, the primary analysis demonstrated a survival benefit for patients receiving high-dose hemodiafiltration (HDF) as compared with high-flux hemodialysis (HD). A secondary objective was to evaluate effects on health-related quality of life (HRQoL); assessed in eight domains (physical function, cognitive function, fatigue, sleep disturbance, anxiety, depression, pain interference, social participation) applying instruments from the Patient-Reported Outcome Measurement Information System (PROMIS) before randomization and every three months thereafter.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
More positive data from CONVINCE Not just living longer but better on HDF vs HD Any US physicians have HDF in their unit yet? https://t.co/RLvGJsfJb4
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Mashup Score: 291Deciphering the kidney hemodynamic effects of SGLT2 inhibition: translating insights from rats to humans in type 2 diabetes - 8 month(s) ago
The attenuation of glomerular hyperfiltration is posited to be a principal mechanism underlying the kidney protective effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors in diabetic kidney disease. Notably, the impact of SGLT2 inhibitors on kidney hemodynamic function has been posited to vary between type 1 and type 2 diabetes. The study by Wada et al. documents that in an animal model of type 2 diabetes, SGLT2 inhibitors mitigate glomerular hyperfiltration predominantly through afferent arteriolar constriction, a process mediated by the adenosine/A1 receptor pathway.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
Deciphering the kidney hemodynamic effects of #SGLT2 inhibition: translating insights from rats to humans in type 2 diabetes https://t.co/bYbGv22V4z Original article: https://t.co/Fuk5dIXyGq @UWDeptMedicine @medcmuofficial #KICommentary #diabetes https://t.co/S8i6hz1nqL
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Mashup Score: 6Individual and neighborhood-level social and deprivation factors impact kidney health in the GLOMMS-CORE study - 8 month(s) ago
Prospective cohort studies of kidney equity are limited by a focus on advanced rather than early disease and selective recruitment. Whole population studies frequently rely on area-level measures of deprivation as opposed to individual measures of social disadvantage. Here, we linked kidney health and individual census records in the North of Scotland (Grampian area), 2011-2021 (GLOMMS-CORE) and identified incident kidney presentations at thresholds of estimated glomerular filtration rate (eGFR) under 60 (mild/early), under 45 (moderate), under 30 ml/min/1.73m2 (advanced), and acute kidney disease (AKD).
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
Individual and neighborhood-level social and deprivation factors impact #kidneyhealth in the GLOMMS-CORE study https://t.co/PeAXlkRSmx @AbdnCHDS @ENUHealthSocial @EdinburghNapier @PrimaryCareMcr @profcorrib @UoS_PrimaryCare @LSHTM @Sydney_Uni #OpenAccess #CKD https://t.co/bjQBeEFb3k
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Mashup Score: 196Clinical validation of the novel fluorescent glomerular filtration rate tracer agent relmapirazin (MB-102) - 8 month(s) ago
The fluorescent compound relmapirazin has been rationally designed for use in point-of-care measurement of glomerular filtration rate (GFR), with attributes including negligible protein binding, negligible metabolites in vivo, negligible tubular secretion, and excellent chemical and photo stability. Twenty-four nonclinical assays were performed in accordance with FDA requirements yielding negligible toxicology concerns. Here, a clinical study was performed to validate relmapirazin as a GFR tracer in patients by comparison to iohexol.
Source: www.kidney-international.orgCategories: General Medicine News, NephrologyTweet-
I'm excited to see this true GFR measurement drug/device nearing FDA approval. Imagine injecting a inert fluoroprobe, slapping a pulse-ox like monitor on them and in less than 1 hr knowing their mGFR. You could also monitor for changes in mGFR over12-24h. https://t.co/qhyS4e7sN1
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Just out @Kidney_Int https://t.co/mEyvFw9bU2 Diagnosis and Management of Immune Checkpoint Inhibitor-Associated Nephrotoxicity: A Position Statement from the American Society of Onco-nephrology @onconephsociety @onconeph @HerrmannMd @renalmyeloma @ShrutiGkidney @ArashRashidi14