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Mashup Score: 6
Adults with congenital heart disease make up most patients with congenital heart disease vastly surpassing the pediatric patients largely because of significant improvements in the medical, interventional, and surgical approaches. An increasing body of evidence highlights the impact of noncardiac morbidity and mortality in these patients. Malignancy is a known major cause of death in adult patients with congenital heart disease. The causes are multifactorial, including genetics, radiation, delayed age-appropriate screening, anatomy variations, and thymectomy. This article provides an overview of the specific risk factors and how health care providers and patient education can mitigate some of these risk factors.
Source: www.cardiology.theclinics.comCategories: General Medicine News, CardiologistsTweet
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Mashup Score: 3Classes of Antineoplastic Agents Associated with Increased Risk of Cancer Therapy-associated Hypertension and Management Strategies - 5 month(s) ago
Hypertension (HTN) has been found to be the most common comorbidity in patients with cancer. In addition to increased prevalence of baseline HTN, patients with cancer may be at increased risk of HTN as a short-term or long-term adverse event from cancer therapy. Different classes of cancer therapies have been implicated in the development of HTN, including inhibitors of vascular endothelial growth factor (VEGF), Bruton tyrosine kinase inhibitors, proteasome inhibitors, androgen deprivation therapy, and others. While some of these drugs may lead to increases in blood pressure through on-target effects (eg, with VEGF inhibition), others may be associated with HTN from off-target mechanisms that are not always well understood.
Source: www.cardiology.theclinics.comCategories: General Medicine News, CardiologistsTweet-
Want to know how help manage unique causes of HTN in #cardioonc? @StanfordCVI #hodasayegh @Ron_Witteles @HanZhuMD @SWaliany et al provide a great overview on HTN in cancer, as well as unusual drug classes that can exacerbate/cause HTN (ie VEGFi!) https://t.co/fa9KhrEtHr 6/🧵 https://t.co/dJKMyPRII2
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Mashup Score: 6
Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related phenomenon in which somatic mutations lead to clonal expansion of hematopoietic stem cells without the development of hematologic abnormalities. A growing body of literature demonstrates an association between CHIP and cardiovascular disease. This pathophysiology demonstrates a novel connection between global inflammation and cardiovascular morbidity. While there is limited consensus addressing the cardiovascular care of these patients, risk factor optimization and disease surveillance are advisable. Investigation into possible therapies is ongoing and provides promise for the treatment of inflammation contributing to cardiovascular disease in patients with and without CHIP.
Source: www.cardiology.theclinics.comCategories: General Medicine News, CardiologistsTweet-
...@uclaCVfellows STAR #bruinhearts fellow @MichaelR21 @AlexBickMDPhD provide this great overview of the increasing potential and role of clonal hematopoiesis of indeterminate potential & itsassociations w/ CV disease. #CHIP https://t.co/KeN6MwdUdM 4/ 🧵 https://t.co/FEgJNxcxuu
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Mashup Score: 11Cardiovascular Risk Assessment and Prevention in Cardio-Oncology - 5 month(s) ago
This review goes beyond traditional approaches in cardio-oncology, highlighting often-neglected factors impacting patient care. Social determinants, environment, health care access, and gut microbiome significantly influence patient outcomes. Powerful tools like multi-omics and wearable technologies offer deeper insights into real-world experiences. The future lies in integrating these advancements with established practices to achieve precision cardio-oncology care. By crafting tailored therapies and continuously updating comprehensive management plans based on real-time data, we can unlock the full potential of personalized care for all patients.
Source: www.cardiology.theclinics.comCategories: General Medicine News, CardiologistsTweet-
Next, #OmarMakram @NainPriyanshu @avirupguha et al discuss the broad challenges--and opportunities--in understanding the complex interplay of CV risk assessment and prevention in #cardioonc...beyond traditional risk factors https://t.co/eTK4qMWcNj 3/🧵 https://t.co/4Qf3kqylLA
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Mashup Score: 3Addressing the Growing Intersectionality of Cancer and Heart Disease: The Rise of Cardio-Oncology - 5 month(s) ago
With significant strides in cancer treatment and survivorship, the reach and scope of Cardio-Oncology has extended beyond its traditional, perceived association with chemotherapy-induced heart failure to encompass every facet of the cardiovascular landscape intersecting with an expanding array of anticancer therapies. With over 20 million cancer survivors expected in the United States alone by 2030,1 understanding, predicting, and treating the cardiovascular health of the growing cancer population is paramount.
Source: www.cardiology.theclinics.comCategories: General Medicine News, CardiologistsTweet-
First, @A_SteinMerlob & I open up with the importance of examining the intersectionality of cancer and heart disease Why is this important to not just #cardioonc specialists, but to health care professionals in BOTH fields as a whole? Read below: https://t.co/RtC05bQTKr 2/🧵 https://t.co/dmt4pT9Neu
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Mashup Score: 60Left Bundle Branch Block - 6 month(s) ago
Left bundle branch block (LBBB) is not just a simple electrocardiogram alteration. The intricacies of this general terminology go beyond simple conduction block. This review puts together current knowledge on the historical concept of LBBB, clinical significance, and recent insights into the pathophysiology of human LBBB. LBBB is an entity that affects patient diagnosis (primary conduction disease, secondary to underlying pathology or iatrogenic), treatment (cardiac resynchronization therapy or conduction system pacing for heart failure), and prognosis. Recruiting the left bundle branch with conduction system pacing depends on the complex interaction between anatomy, site of pathophysiology, and delivery tools.
Source: www.cardiology.theclinics.comCategories: General Medicine News, CardiologistsTweet-
RT @ZHeart11768530: Left Bundle Branch Block https://t.co/9k4znpVLdr #CardioEd #Cardiology #EPeeps https://t.co/E7GJeQExPh
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Mashup Score: 8Initial Triage and Management of Patients with Acute Aortic Syndromes - 12 month(s) ago
The acute aortic syndromes (AAS) are life-threatening vascular compromises within the aortic wall. These include aortic dissection (AD), intramural hematoma (IMH), penetrating aortic ulcer (PAU), and blunt traumatic thoracic aortic injury (BTTAI). While patients classically present with chest pain, the presentation may be highly variable. Timely diagnosis is critical to initiate definitive treatment and maximize chances of survival. In high-risk patients, treatment should begin immediately, even while diagnostic evaluation proceeds. The mainstay of medical therapy is acute reduction of heart rate and blood pressure. Surgical intervention is often required but is informed by patient anatomy and extent of vascular compromise.
Source: www.cardiology.theclinics.comCategories: General Medicine News, Cardiologists1Tweet-
https://t.co/k3TntGDU6i
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Mashup Score: 7Acute Heart Valve Emergencies - 1 year(s) ago
Within the cardiac intensive care unit, prompt recognition of severe acute valvular lesions is essential because hemodynamic collapse can occur rapidly, especially when cardiac chambers have not had time for compensatory remodeling. Within this context, optimal medical management, considerations for temporary mechanical circulatory support and decisive treatments strategies are addressed. Fundamental concepts include an appreciation for how sudden changes in flow and pressure gradients between cardiac chambers can impact hemodynamic and echocardiographic findings differently compared to similarly severe chronic lesions, as well as understanding the main causes for decompensated heart failure and cardiogenic shock for each valvular abnormality.
Source: www.cardiology.theclinics.comCategories: General Medicine News, Cardiologists1Tweet-
https://t.co/qK7r84YHEu
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Mashup Score: 7Acute Heart Valve Emergencies - 1 year(s) ago
Within the cardiac intensive care unit, prompt recognition of severe acute valvular lesions is essential because hemodynamic collapse can occur rapidly, especially when cardiac chambers have not had time for compensatory remodeling. Within this context, optimal medical management, considerations for temporary mechanical circulatory support and decisive treatments strategies are addressed. Fundamental concepts include an appreciation for how sudden changes in flow and pressure gradients between cardiac chambers can impact hemodynamic and echocardiographic findings differently compared to similarly severe chronic lesions, as well as understanding the main causes for decompensated heart failure and cardiogenic shock for each valvular abnormality.
Source: www.cardiology.theclinics.comCategories: General Medicine News, Cardiologists1Tweet-
https://t.co/qK7r84YHEu
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Mashup Score: 110Bilateral Bundle Branch Block - 1 year(s) ago
Left bundle branch block (LBBB) and right bundle branch block (RBBB) are classic manifestations of bundle branch conduction disorders. However, a third form that is uncommon and underrecognized may exist that has features and pathophysiology of both: bilateral bundle branch block (BBBB). This unusual form of bundle branch block exhibits an RBBB pattern in lead V1 (terminal R wave) and an LBBB pattern in leads I and aVL (absence of S wave). This unique conduction disorder may confer an increased risk of adverse cardiovascular events. BBBB patients may be a subset of patients that respond well to cardiac resynchronization therapy.
Source: www.cardiology.theclinics.comCategories: General Medicine News, CardiologistsTweet-
RT @ZHeart11768530: Bilateral Bundle Branch Block https://t.co/j9jvuqYeKh #CardioEd #Cardiology #EPeeps https://t.co/1fU739vxEE
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Cancer rates are ⏫ In the ⏫ #ACHD population...esp at younger ages. This unique population, through their unusual CV pathophysiology & unknown cardiotoxicity profile deserve further study, as highlighted by @UCLAHealth #gentianlluri @PVenkateshMD https://t.co/RYuNPNfiZ6 5/🧵 https://t.co/Tvfny5uZ4k