• Mashup Score: 0
    Cardiovascular Aging and Exercise: Implications for Heart Failure Prevention and Management | Circulation Research - 4 hour(s) ago

    A demographic shift toward an aging population is occurring worldwide. Commensurate with this trend, age-related diseases are also rising. Although aging is an immutable part of life, biological aging is a highly heterogeneous process influenced by health-related behaviors, genetics, and the environment. The biological effects of aging are evident across all organ systems. Some individuals demonstrate an accelerated aging phenotype, which is associated with substantial morbidity and mortality. Moreover, common cardiovascular conditions, such as heart failure with preserved ejection fraction, can be conceptualized as a consequence of accelerated aging. Physical activity and exercise training modify the biological effects of accelerated aging considerably. They are associated with various salutary benefits and have emerged as potent therapeutics in disease states characterized by the accelerated aging phenotype. In this state-of-the-art review, we discuss the age-related changes observed

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircRes
      CircRes

      @CircRes Compendium on #Cardiopulmonary Disease and #Exercise #Cardiovascular #Aging and Exercise: Implications for Cardiovascular Disease Prevention and Management https://t.co/3WXhGkv8S1 Authored by @vinayaksub & colleagues @ambarish4786 @WesleyTux1333 @aepetersMD https://t.co/0xZ44ppr3C

  • Mashup Score: 7
    Exercise Training in Heart Failure: Clinical Benefits and Mechanisms | Circulation Research - 1 day(s) ago

    Clinical guidelines broadly recommend exercise training for patients with heart failure (HF). This review examines clinical benefits of exercise training across HF subtypes, focusing on clinical trials with key outcomes including mortality, hospitalization, exercise capacity, and quality of life. We also explore physiological and molecular mechanisms by which exercise training may improve HF, including organ-specific effects along the oxygen transport pathway from the cardiopulmonary system to the peripheral vasculature and skeletal muscles. We further review global mechanisms underlying the benefits of exercise training in HF, including antiinflammatory, immunomodulatory, and antioxidative effects, in addition to neurohormonal regulation and interorgan crosstalk. Finally, we identify future research directions to refine and support evidence-based exercise training prescriptions for HF management.

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircRes
      CircRes

      @CircRes Compendium on #Cardiopulmonary Disease and #Exercise Exercise Training in #HeartFailure: Clinical Benefits and Mechanisms https://t.co/iwGDLNxYNo Authored by @LouisaMounsey & colleagues @JenHoCardiology @emilyswlau https://t.co/TPVLG1pWYM

  • Mashup Score: 22
    Guideline-Directed Medical Therapy Use in the STRONG-HF Trial | Circulation: Heart Failure - 2 day(s) ago

    BACKGROUND: Assessment of medication changes in heart failure trials and registries is complex and may not capture the entirety of care. A comprehensive and standardized method is needed. We used different methods to assess the use of guideline-directed medical therapies (GDMT) and verified the association between GDMT intensity score with the STRONG-HF trial (Safety, Tolerability and Efficacy of Rapid Optimization, Helped by NT-proBNP Testing of Heart Failure Therapies) clinical outcomes. METHODS: We used data from the STRONG-HF trial to examine the baseline GDMT use for all randomized patients by applying the GDMT intensity score and evaluated its change over time. We also examined their basic adherence, indication-corrected adherence, and dose-corrected adherence, and the association with clinical outcomes up to 180 days. RESULTS: At 90 days, triple therapy indication-corrected use increased from 4.5% to 36% in the usual care group, and from 5.2% to 93.5% in the high-intensity care

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircHF
      CircHF

      Guideline-Directed Medical Therapy Use in the STRONG-HF Trial @AdriaanVoors @lamcardio @MarcoMetra @justinezekowitz @CVC_UAlberta #AHAJournals https://t.co/KGVju5K7bi https://t.co/BNfRCzjL6g

  • Mashup Score: 18
    The State of Cardiovascular Care in Peru: Needs for System Strengthening | Circulation - 2 day(s) ago

    Peru’s geography includes coastal, Andean, and Amazonian regions, with populations living at sea level to altitudes of 4000 meters or more. In 2021, the population was 33.7 million, with a Gini index of 40.2, a life expectancy of 72.4 years, and 79% living in urban areas. Obesity affected 26% of the population, along with hypertension (17%) and diabetes (5%). In 2 decades, noncommunicable diseases deaths rose from 55% in 2000 to 73% in 2019, while deaths from communicable diseases fell from 33% to 17%.

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircAHA
      CircAHA

      #JustPublished: The State of Cardiovascular Care in Peru: Needs for System Strengthening https://t.co/vfovR0UolB https://t.co/5YPWz0sZZc

  • Mashup Score: 114
    New Algorithm for Estimating Left Ventricular Filling Pressure by Echocardiography | Circulation - 2 day(s) ago

    BACKGROUND: Evaluation of whether dyspnea has a cardiac cause is essential. Guidelines from 2016 were reported to result in a high incidence of indeterminate left ventricular (LV) filling pressure. We sought to validate a new algorithm for the estimation of LV filling pressure (LVFP) in a multicenter study, with the objective of decreasing the yield of indeterminate filling pressure and increasing accuracy. METHODS: In an observational study, echocardiography was performed in 951 patients referred for cardiac catheterization. Echocardiographic measurements included mitral inflow, pulmonary vein and tissue Doppler mitral annulus velocities, tricuspid regurgitation velocity, assessment of mean right atrial pressure, biplane LV and left atrial volumes, and LV and left atrial strain. A stepwise approach was applied in a new algorithm for estimation of LVFP, whereby pressure >15 mm Hg was considered abnormally elevated. The first step included mitral annulus early diastolic velocity (e′), t

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircAHA
      CircAHA

      A new echocardiographic algorithm provides accurate classification of left ventricular filling pressure, reducing indeterminate cases, particularly in patients with preserved ejection fraction. @SNagueh https://t.co/JPyxVhlXtD https://t.co/jnb0wwte3i

  • Mashup Score: 15
    Mitochondrial Tumor Suppressor 1A Attenuates Myocardial Infarction Injury by Maintaining the Coupling Between Mitochondria and Endoplasmic Reticulum | Circulation - 2 day(s) ago

    BACKGROUND: Pathological cardiac remodeling after myocardial infarction (MI) is a leading cause of heart failure and sudden death. The detailed mechanisms underlying the transition to heart failure after MI are not fully understood. Disruptions in the endoplasmic reticulum (ER)–mitochondria connectivity, along with mitochondrial dysfunction, are substantial contributors to this remodeling process. In this study, we aimed to explore the impact of mitochondrial tumor suppressor 1A (Mtus1A) on cardiac remodeling subsequent to MI and elucidate its regulatory role in ER-mitochondria interactions. METHODS: Single-nucleus RNA sequencing analysis was performed to delineate the expression patterns of Mtus1 in human cardiomyocytes under ischemic stress. MI models were induced in mice by left coronary artery ligation and replicated in vitro using primary neonatal rat ventricular myocytes exposed to oxygen glucose deprivation. Cardiac-specific deletion of Mtus1 was achieved by crossing floxed Mtus

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircAHA
      CircAHA

      Mtus1A preserves ER–mitochondria coupling post-MI. Its loss drives remodeling; restoration improves mitochondrial and cardiac function. A promising post-MI target. https://t.co/3kTg4bvjoo https://t.co/RJKQF2ealg

  • Mashup Score: 1
    Anti-TRPV2 Autoantibody Linked to Sudden Infant Death Syndrome | Circulation - 2 day(s) ago

    As a leading cause of infant death, sudden infant death syndrome (SIDS) remains a perplexing diagnosis with no clear underlying biological substrate. 1 In the past decade, studies have emerged demonstrating that circulating autoantibodies targeting cardiac antigens can underlie life-threatening arrhythmias. 2 Because autoimmunity as a cause of SIDS has not yet been explored, we screened infant serum samples for the presence of autoantibodies targeting cardiac ion channels and examined how immunoglobulins

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of CircAHA
      CircAHA

      Autoantibodies against the TRPV2 channel, that allows calcium influx into cardiomyocytes, is significantly associated with Sudden Infant Death Syndrome https://t.co/qrmBFqrSK8 https://t.co/l07QKEpiXi

  • Mashup Score: 12
    Advice and Tips for Achieving Work-Life Balance for Early Career Researchers | Stroke - 2 day(s) ago

    View all available purchase options and get full access to this article. Bartlett MJ, Arslan FN, Ba nkston A, Sarabipour S. Ten simple rules to improve academic work-life balance. PLoS Comput Biol. 2021;17:e1009124. doi: 10.1371/journal.pcbi.1009124 Dominika Kwasnicka AYL, Krull Abe S, Carey R, Caudwell KM, Yan Chan AH, Desveaux L, Fleuren B, Fowler LA, Gatari E, Graham AK, et al. Survival Guide for Early Career Researchers. 1st ed. Springer Cham; 2022 Nxele SR. A wish list to improve postdoctoral life.

    Source: www.ahajournals.org
    Categories: General Medicine News
    Tweet Tweets with this article
    • Profile photo of StrokeAHA_ASA
      StrokeAHA_ASA

      #STROKE InterSECT article by Mamtilahun et al. discusses opportunities and challenges in navigating work-life balance, especially for those in the early career phase. #AHAJournals https://t.co/pq2ugGlriy https://t.co/FTledSNMAU

Load More