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Mashup Score: 8
Aims/hypothesis Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH) examined the acute response to metformin and glipizide in order to identify new pharmacogenetic…
Source: SpringerLinkCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Adjuvant and neoadjuvant use of immune checkpoint inhibitors in NSCLC - Journal of Cancer Research and Clinical Oncology - 2 year(s) ago
The neoadjuvant and adjuvant use of immune checkpoint inhibitors (ICIs) in early stage non-small cell lung cancer (NSCLC) is increasing, with pembrolizumab approved as adjuvant therapy following surgical resection and chemotherapy by the U.S. Food and Drug Administration in early 2023. However, clinical trials of these agents have several key limitations including the use of surrogate endpoints…
Source: SpringerLinkCategories: Expert Picks, Latest HeadlinesTweet-
Key Question in #KN671 is how many people on control arm who progressed got Pembro+chemo (vs. chemo alone which is not SOC)? Here is some data from prior trials in our OA paper 57% of treated controls got CPI. That is poor #ASCO23 OS is meaningless https://t.co/k6Rl54vUgs https://t.co/El7cz5eMWg
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Mashup Score: 1
Background Adjuvant immune checkpoint blockade (ICB) following chemoradiotherapy and adding ICB to chemotherapy have been key advances for stages III-IV non-small cell lung cancer (NSCLC) treatment. However, known biomarkers like PD-L1 are not consistently indicative of ICB response. Other markers within the tumor immune microenvironment (TIME) may better reflect ICB response and/or resistance…
Source: SpringerLinkCategories: Hem/Oncs, Latest HeadlinesTweet-
Comparison of the tumor immune microenvironment and checkpoint blockade biomarkers between stage III and IV non-small cell lung cancer [Jul 26, 2022] @YinjieGao et al. Cancer Immunology, Immunotherapy https://t.co/Krcz0RVTWV #ImmunoOnc #lcsm #PrecisionMedicine https://t.co/7BIWSg1rmt
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Mashup Score: 20
Aim/hypothesis This study aimed to investigate the safety and efficacy of treatment with allogeneic Wharton’s jelly-derived mesenchymal stromal cells (MSCs) in recent-onset type 1 diabetes. Methods A combined Phase I/II trial, composed of a dose escalation followed by a randomised double-blind placebo-controlled study in parallel design, was performed in which treatment with allogeneic MSCs…
Source: SpringerLinkCategories: General Medicine News, Latest HeadlinesTweet-
Wharton's jelly found to halt diabetes progression in Phase II trial https://t.co/uSfMfNl8HS https://t.co/gVt1j97Q5H
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Mashup Score: 1Hierarchical status is rapidly assessed from behaviourally dominant faces - Cognitive, Affective, & Behavioral Neuroscience - 2 year(s) ago
Recognition of social hierarchy is a key feature that helps us navigate through our complex social environment. Neuroimaging studies have identified brain structures involved in the processing of hierarchical stimuli, but the precise temporal dynamics of brain activity associated with such processing remains largely unknown. In this investigation, we used event-related potentials (ERPs) to…
Source: SpringerLinkCategories: General Medicine News, Latest HeadlinesTweet-
How our brains can rapidly identify people in power @uq_news https://t.co/dbfpyPUaB1 https://t.co/lfttiE2Hm2
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Mashup Score: 1Loneliness as Cause - Topoi - 2 year(s) ago
While loneliness has been linked to various mental and physical health problems, the sense in which loneliness is a cause of these conditions has so far attracted little philosophical attention. This paper aims to fill this gap by analyzing research on health effects of loneliness and therapeutic interventions through current approaches to causality. To deal with the problem of causality between…
Source: SpringerLinkCategories: Hem/Oncs, Latest HeadlinesTweet-
Loneliness as Cause https://t.co/l4BzRhqF6O via @ElenaPopaPhi
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Mashup Score: 0How much sport is too much? A focus on musculoskeletal health of the adult - Aging Clinical and Experimental Research - 2 year(s) ago
Aging Clinical and Experimental Research –
Source: SpringerLinkCategories: Hem/Oncs, Latest HeadlinesTweet-
How much sport is too much? A focus on musculoskeletal health of the adult https://t.co/vY6LOq37Eo via @olibruyere et al
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Mashup Score: 0Management of paraesophageal hiatus hernia: recommendations following a European expert Delphi consensus - Surgical Endoscopy - 2 year(s) ago
Aims There is considerable controversy regarding optimal management of patients with paraesophageal hiatus hernia (pHH). This survey aims at identifying recommended strategies for work-up, surgical therapy, and postoperative follow-up using Delphi methodology. Methods We conducted a 2-round, 33-question, web-based Delphi survey on perioperative management (preoperative work-up, surgical procedure…
Source: SpringerLinkCategories: Healthcare Professionals, Latest HeadlinesTweet-
Management of paraesophageal hiatus hernia: recommendations following a European expert Delphi consensus | SpringerLink https://t.co/MPwXUcIlL3
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Mashup Score: 3Limitations of “Limitations of Bayesian Leave-one-out Cross-Validation for Model Selection” - Computational Brain & Behavior - 2 year(s) ago
In an earlier article in this journal, Gronau and Wagenmakers (2018) discuss some problems with leave-one-out cross-validation (LOO) for Bayesian model selection. However, the variant of LOO that Gronau and Wagenmakers discuss is at odds with a long literature on how to use LOO well. In this discussion, we discuss the use of LOO in practical data analysis, from the perspective that we need to…
Source: SpringerLinkCategories: Infectious Disease, Latest HeadlinesTweet-
Some useful discussion on model selection, especially when models are nested (i.e. one is simpler version of other for certain parameter values): https://t.co/BloSYtw7VL
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Mashup Score: 0
Background Older adults’ mental health and physical frailty have been a frequent research focus, but few studies have investigated the relationship between them. Objectives To investigate the association between mental health and physical frailty in community-dwelling older Japanese people. Design Cross-sectional study from the Itoshima Frail Study. Setting Itoshima City, Fukuoka, Japan….
Source: SpringerLinkCategories: Geriatrics, Latest HeadlinesTweet-
Liu, X., Chen, T., Chen, S. et al. The Relationship between Psychological Distress and Physical Frailty in Japanese Community-Dwelling Older Adults: A Cross-Sectional Study. J Frailty Aging 12, 43–48 (2023). https://t.co/sAT4vB8kqZ
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Genetic variants may affect treatment response to commonly prescribed type 2 #diabetes medication https://t.co/fMQNhUCnGO https://t.co/YSU98mLxRe