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Mashup Score: 2Lymph node stromal cells: cartographers of the immune system - 5 year(s) ago
Turley and Krishnamurty review new insights into lymph node stromal cells, a heterogeneous cell population that serves distinct functions during development, in maintaining lymphocyte homeostasis, and in coordinating immune responses.
Source: Nature ImmunologyCategories: Hem/OncsTweet
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Mashup Score: 5PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer - 5 year(s) ago
PD-L1 on tumor cells exerts an important dampening effect on T cells via their expression of PD-1. Miller and colleagues find that PD-L1 ‘back-signaling’ into T cells and macrophages can also dampen immune responses within the tumor microenvironment.
Source: Nature ImmunologyCategories: Hem/Onc News and JournalsTweet-
PD-L1 engagement on T cells promotes self-tolerance and suppression of the PD-L1 expressing T cell as well as neighbouring macrophages and effector T cells in cancer: https://t.co/Ms43Si8cFd #ImmunoOnc
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Mashup Score: 0Vincenzo Cerundolo 1959–2020 - 5 year(s) ago
“Whatever mourns… / Whatever shares / The eternal reciprocity of tears.” —Wilfred Owen
Source: Nature ImmunologyCategories: Hem/OncsTweet-
A beautiful tribute to our much-missed friend and colleague Enzo Cerundolo in @NatImmunol by Prof Alain Townsend. “Life is an experiment you can’t repeat.” https://t.co/OJnhc4SE0u
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Mashup Score: 7Distinct microbial and immune niches of the human colon - 5 year(s) ago
The gut microbiota and their proximate immune cells engage in a dialog of reciprocal regulation. James and colleagues describe how immune cell and microbiotal populations vary along the length of the human colon.
Source: Nature ImmunologyCategories: GastroenterologyTweet-
#GastroEdPick New study assesses the #microbiota and immune cells across the human colon to identify immune niches. E.g. they show increasing B cells and clonal expansion from the cecum to the sigmoid colon, linked to no. of bacterial species @NatImmunol https://t.co/CF6C7yYbvA
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Mashup Score: 0B is for ‘Big Mac’: GCs crave a high-fat diet - 5 year(s) ago
Highly proliferative cells have classically been thought to rely on anaerobic glycolysis for fuel. Weisel et al. show that germinal center B cells break this rule, as they primarily utilize fatty acid oxidation to meet their metabolic demands.
Source: Nature ImmunologyCategories: Hem/OncsTweet-
Germinal center B cells primarily utilize fatty acid oxidation to meet their metabolic demands. https://t.co/maVYGuwYcf
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Mashup Score: 2CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors - 5 year(s) ago
Tumor environments are highly acidic due to high concentrations of lactic acid. Ho and colleagues report that tumor-infiltrating regulatory T cells adapt to this tumor environment by upregulating expression of CD36, which allows them to use fatty acids to fuel their metabolism.
Source: Nature ImmunologyCategories: Hem/OncsTweet-
CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors | Nature Immunology https://t.co/MNY53OQkQ9
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Mashup Score: 2CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors - 5 year(s) ago
Tumor environments are highly acidic due to high concentrations of lactic acid. Ho and colleagues report that tumor-infiltrating regulatory T cells adapt to this tumor environment by upregulating expression of CD36, which allows them to use fatty acids to fuel their metabolism.
Source: Nature ImmunologyCategories: Hem/OncsTweet-
RT @AlvaroLladser: CD36-mediated metabolic adaptation supports regulatory T cell survival and function in tumors https://t.co/mO9iMH2uFX
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Mashup Score: 9Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1 - 5 year(s) ago
Identifying selective tumor-associated molecules that can act as targets for T cells is a major goal of immunotherapy. Sewell and colleagues demonstrate that the nonclassical MHC molecule MR1 is expressed on a wide variety of cancer types and can be targeted by conventional T cells.
Source: Nature ImmunologyCategories: Future of Medicine, Latest HeadlinesTweet-
A human T cell receptor directs tumor cell killing via recognition of MR1 and cancer cell-derived metabolites https://t.co/gfZT0Ym1Kj #NBThighlight
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Mashup Score: 25Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1 - 5 year(s) ago
Identifying selective tumor-associated molecules that can act as targets for T cells is a major goal of immunotherapy. Sewell and colleagues demonstrate that the nonclassical MHC molecule MR1 is expressed on a wide variety of cancer types and can be targeted by conventional T cells.
Source: Nature ImmunologyCategories: Healthcare ProfessionalsTweet-
Discovery of a T cell receptor clone (via genome-wide #CRISPR) with the potential of pan-#cancer, pan-population immunotherapy https://t.co/zajXQdSa0D @NatImmunol by @CUSystemsImmu @cardiffuni's Andy Sewell and collaborators https://t.co/sybhKj1Vag https://t.co/wFdmhbxXos
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Mashup Score: 5Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1 - 5 year(s) ago
Identifying selective tumor-associated molecules that can act as targets for T cells is a major goal of immunotherapy. Sewell and colleagues demonstrate that the nonclassical MHC molecule MR1 is expressed on a wide variety of cancer types and can be targeted by conventional T cells.
Source: Nature ImmunologyCategories: Hem/OncsTweet-
Genome-wide CRISPR–Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1 | Nature Immunology https://t.co/OsGCw8PUKz
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RT @mmw_lmw: #LymphNode #StromalCells | During LN organogenesis | ShannonTurley @genentech @NatImmunol https://t.co/XGMWQoRw4F https://t.co…