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Mashup Score: 13Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration - 4 year(s) ago
Quail and colleagues demonstrate that neutrophil-derived ROS and extracellular traps (NETs) mediate breast cancer metastasis to the lungs by altering endothelial junctional adhesions, thus favoring vascular permeability and transendothelial migration of cancer cells.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 24A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types - 4 year(s) ago
Robbins and colleagues develop and test a machine learning neoantigen ranking model using experimentally validated neoantigens from human tumors, providing a resource of targetable neoantigens for future immunotherapies.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
⭐️ICYMI @NatureCancer: "A #MachineLearning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types" by Paul F. Robbins &Co @theNCI Don't miss it! 👇👇 https://t.co/K04eE3JkiM https://t.co/X9WXjJ5Z8S #cancer #Immunotherapy https://t.co/zN0h7NnAZF
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Mashup Score: 0Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration - 4 year(s) ago
Quail and colleagues demonstrate that neutrophil-derived ROS and extracellular traps (NETs) mediate breast cancer metastasis to the lungs by altering endothelial junctional adhesions, thus favoring vascular permeability and transendothelial migration of cancer cells.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
The neutrophils at it again.... Another reason to watch those carbs 🍩 Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration | Nature Cancer #hemepath #endcancer https://t.co/PBTTxE2EPm
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Mashup Score: 85Overcoming therapy resistance in EGFR-mutant lung cancer - 4 year(s) ago
Passaro and colleagues discuss recent advances in treating EGFR-mutant lung cancer, including methods for detecting disease and tracking therapy response, developments in understanding of resistance mechanisms and ongoing clinical trials to circumvent therapeutic resistance to EGFR targeting.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
Excellent review on the mechanisms of acquired EGFR TKI resistance, the methods for monitoring its appearance, as well as efforts to define treatment strategies to overcome resistance @NatureCancer https://t.co/vmOaInFgTB https://t.co/kZ759jYQY2
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Mashup Score: 3A global effort to understand the riddles of COVID-19 and cancer - 4 year(s) ago
Cancer has found a formidable foil in COVID-19, and this has brought to the fore the early concerns that COVID-19 could have a deeper impact on oncology patients. Two studies now provide insights into the enigma surrounding the determinants of the worsening of COVID-19 symptoms in patients with cancer.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
⭐️Determinants of mortality for COVID-19 and cancer @NatureCancer +CCC19 registry @COVID19nCCC, UKCCMP, Gustave Roussy cohort, the TERAVOLT registry, the Curie cohort & Veneto region of Italy @OncoAlert https://t.co/L90bYDYfGO https://t.co/SBWJhvzLzu
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Mashup Score: 0A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage - 4 year(s) ago
Nik-Zainal and colleagues leverage CRISPR–Cas9 and whole-genome sequencing to examine mutational patterns following knockout of 42 human DNA repair genes. They further develop and validate a clinically relevant tool to detect mismatch repair-deficient tumors.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage https://t.co/pnaoVYzj4m
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Mashup Score: 10A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage - 4 year(s) ago
Nik-Zainal and colleagues leverage CRISPR–Cas9 and whole-genome sequencing to examine mutational patterns following knockout of 42 human DNA repair genes. They further develop and validate a clinically relevant tool to detect mismatch repair-deficient tumors.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
⚡ONLINE @NatureCancer: "A systematic #CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous #DNAdamage" a tour de force study by @SerenaNikZainal &Co🤩 Don't miss it! 👇👇 https://t.co/v3fWZcZObZ https://t.co/gO3ijplmhJ https://t.co/VlSK17TMAH
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Mashup Score: 25
Ferraro et al. report that fatty acid synthesis is needed for brain cancer metastasis and show that blocking this process by inhibiting fatty acid synthase reduces the metastatic growth of breast cancer cells in the brain.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
🔥Two studies @NatureCancer and @Nature by @mvh_lab, #ToddGolub &Co show that fatty acid #metabolism is required for brain #metastasis Find them here! 👇 https://t.co/cX01KQYnbs https://t.co/IADcPtS9dl And the NVs by @almut_schulze &Co: https://t.co/adzYiKzMSC https://t.co/MQ1TPkrMXL
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Mashup Score: 5A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage - 4 year(s) ago
Nik-Zainal and colleagues leverage CRISPR–Cas9 and whole-genome sequencing to examine mutational patterns following knockout of 42 human DNA repair genes. They further develop and validate a clinically relevant tool to detect mismatch repair-deficient tumors.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage | Nature Cancer https://t.co/XQMv18l616
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Mashup Score: 5EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer - 4 year(s) ago
Ellis and colleagues show that combination of EZH2 inhibition and anti-PD-1 can increase antitumor immune responses in typically ‘immune cold’ prostate cancer, by increasing EZH2-regulated dsRNA–STING–ISG response signaling.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
Excited to share-our recent @NatureCancer paper has led to initiation of a neoadj trial in #ProstateCancer patients w #Tazemetostat from @EpizymeRx @CSCancerCare @EdwinPosadasMD @TimDaskivich @soulehoward1 @PCF_Science https://t.co/OcIrVMo167
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⭐️ONLINE NOW @NatureCancer: "#Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration" by @DanielaQuail @loganawalsh &Co Find the paper here! 👇👇 https://t.co/1WkNHDy1oD https://t.co/XGAUkrz4fN #metastasis #cancer #obesity https://t.co/cALbsD3x49