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Mashup Score: 1Crowdsourcing a crisis response for COVID-19 in oncology - 4 year(s) ago
Crowdsourcing efforts are currently underway to collect and analyze data from patients with cancer who are affected by the COVID-19 pandemic. These community-led initiatives will fill key knowledge gaps to tackle crucial clinical questions on the complexities of infection with the causative coronavirus SARS-Cov-2 in the large, heterogeneous group of vulnerable patients with cancer.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 1Crowdsourcing a crisis response for COVID-19 in oncology - 4 year(s) ago
Crowdsourcing efforts are currently underway to collect and analyze data from patients with cancer who are affected by the COVID-19 pandemic. These community-led initiatives will fill key knowledge gaps to tackle crucial clinical questions on the complexities of infection with the causative coronavirus SARS-Cov-2 in the large, heterogeneous group of vulnerable patients with cancer.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
Crowdsourcing a crisis response for COVID-19 in oncology [Apr 21, 2020] @ADesaiMD @hemoncwarner @NicoleKuderer @mtmdphd @corrie_painter @gary_lyman @GlopesMd @NatureCancer https://t.co/u71snM3G1F #CCC19 #COVID19nCANCER @COVID19nCCC
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Mashup Score: 4ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer - 4 year(s) ago
Wong and colleagues show that LKB1-deficient lung tumors are sensitive to autophagy inhibition, which can restore impaired antigen presentation and antitumor immune responses, and propose dual targeting of ULK1 and PD-1 for these tumors.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
LKB1 deficiency correlates with an elevated TMB but suppresses antigen processing & presentation, owing to compromised immunoproteasome activity & increased autophagic flux; targeting the ATG1/ULK1 autophagy pathway enhances PD-1 blockade in models: https://t.co/V7o2CpoBRy
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Mashup Score: 32ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1-mutant lung cancer - 4 year(s) ago
Wong and colleagues show that LKB1-deficient lung tumors are sensitive to autophagy inhibition, which can restore impaired antigen presentation and antitumor immune responses, and propose dual targeting of ULK1 and PD-1 for these tumors.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
⭐️ONLINE NOW @NatureCancer: "ULK1 inhibition overcomes compromised #AntigenPresentation and restores #AntitumorImmunity in LKB1-mutant lung cancer", a fantastic study by Kwok-Kin Wong and Co Find it here https://t.co/LzGUVybkHm https://t.co/kVNgkWZQyP #Immunotherapy #LungCancer https://t.co/31FejHO6Hd
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Mashup Score: 21Enhancing anti-tumor immunity by autophagy inhibition - 4 year(s) ago
Two recent studies demonstrate how autophagy, in both tumor cells and host tissues, regulates anti-tumor T cell responses. These works add to accumulating evidence that inhibitors of autophagy could be used in combination with immunotherapy in certain cancer types.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
👉Read the NVs on recent @NatureCancer papers about #autophagy in anti-tumor immune responses, by #AndrewThorburn @CUSystem and @ChristieTowers @salkinstitute https://t.co/Ucck7Af2Ir https://t.co/G65mXjFSVq & the primary papers! https://t.co/AQWXcTmH0j https://t.co/IhiEjzBzdn https://t.co/8DCr0xQOv1 https://t.co/Ag1f9AzPAC
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Mashup Score: 0EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer - 4 year(s) ago
Ellis and colleagues show that combination of EZH2 inhibition and anti-PD-1 can increase antitumor immune responses in typically ‘immune cold’ prostate cancer, by increasing EZH2-regulated dsRNA–STING–ISG response signaling.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
This makes sense as we recently showed a set of ISGs indirectly induced by #EZH2I associated with H3K27ac and Atac peaks. It seems ISGs are more primed for activation rather than fully repressed 🤔?? https://t.co/OcIrVMo167 https://t.co/bVsbYnQCcY
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Mashup Score: 7Combined inhibition of XIAP and BCL2 drives maximal therapeutic efficacy in genetically diverse aggressive acute myeloid leukemia - 4 year(s) ago
Ishikawa and colleagues perform integrated genomic and drug-sensitivity screens with extensive PDX modeling and reveal combined XIAP and BCL2 inhibition as a vulnerability hub across AML genetic alterations.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
RT @NatureJapan: 【日本からの研究成果】Nature Cancer 石川 文彦 / 理化学研究所「XIAPとBCL2の併用阻害は、遺伝的に多様な高悪性度の急性骨髄性白血病において最大の治療効果を促す｣ https://t.co/n7UFuj1bV1 @Natur…
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Mashup Score: 0A global effort to understand the riddles of COVID-19 and cancer - 4 year(s) ago
Cancer has found a formidable foil in COVID-19, and this has brought to the fore the early concerns that COVID-19 could have a deeper impact on oncology patients. Two studies now provide insights into the enigma surrounding the determinants of the worsening of COVID-19 symptoms in patients with cancer.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
⭐️🚨Determinants of mortality for COVID-19 and cancer from published studies @NatureCancer. All the more reason why we need to administer #COVID19Vaccine to all #cancer patients @NatRevClinOncol @OncoAlert @weoncologists https://t.co/L90bYDYfGO https://t.co/o8YclGT62w https://t.co/zCL4eddjcG
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Mashup Score: 0A global effort to understand the riddles of COVID-19 and cancer - 4 year(s) ago
Cancer has found a formidable foil in COVID-19, and this has brought to the fore the early concerns that COVID-19 could have a deeper impact on oncology patients. Two studies now provide insights into the enigma surrounding the determinants of the worsening of COVID-19 symptoms in patients with cancer.
Source: Nature CancerCategories: Hem/Oncs, Latest HeadlinesTweet-
⭐️A global effort to understand the riddles of COVID-19 and cancer @NatureCancer CCC19 registry @COVID19nCCC , UKCCMP, Gustave Roussy @AlbigesL @barlesi @jsoriamd , TERAVOLT registry @myESMO @peters_solange , Curie cohort & Veneto -Italy @curijoey https://t.co/BBOSYrVgHz
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Mashup Score: 4A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types - 4 year(s) ago
Robbins and colleagues develop and test a machine learning neoantigen ranking model using experimentally validated neoantigens from human tumors, providing a resource of targetable neoantigens for future immunotherapies.
Source: Nature CancerCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Researchers develop a machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumour types: https://t.co/G32Vt89CC1 #ImmunoOnc
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Crowdsourcing a crisis response for COVID-19 in oncology [Apr 21, 2020] @ADesaiMD @hemoncwarner @NicoleKuderer @mtmdphd @corrie_painter @gary_lyman @GlopesMd @NatureCancer https://t.co/u71snM3G1F #CCC19 #COVID19nCANCER @COVID19nCCC https://t.co/n0iAFNkkzS