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Mashup Score: 0Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma - 3 year(s) ago
Rescue/recovery workers who responded to the World Trade Center (WTC) attacks were exposed to known/suspected carcinogens. Studies have identified a trend toward an elevated risk of cutaneous melanoma in this population; however, few found significant increases. Furthermore, temporal aspects of the association have not been investigated. A total of 44,540 non-Hispanic White workers from the WTC…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet
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Mashup Score: 0
Central centrifugal cicatricial alopecia (CCCA) is associated with increased expression of genes implicated in fibroproliferative disorders and a higher prevalence of uterine leiomyomas (ULs) among affected individuals. We sought to examine the effect of UL status on the gene expression profile of the lesional scalp in patients with CCCA. Scalp biopsy was obtained from 16 patients with a…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations New study by @CrystalAguhMD @TJamerson_ reveals that uterine leiomyoma status has no impact on the gene expression pattern in the affected scalp of patients with #CCCA #dermtwitter https://t.co/LVU7NkXoWq
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Mashup Score: 4Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity - 3 year(s) ago
Obesity is a growing epidemic worldwide, and it is also considered a major environmental factor contributing to the pathogenesis of inflammatory skin diseases, including psoriasis (PSO) and atopic dermatitis (AD). Moreover, obesity worsens the course and impairs the treatment response of these inflammatory skin diseases. Emerging evidence highlights that hypertrophied adipocytes and infiltrated…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations Great review on how adipose tissue leads to pro inflammatory state that can make #eczema and #psoriasis worse https://t.co/xcRiptaEpv #dermtwitter https://t.co/pLydtdtBAd
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Mashup Score: 0
Atopic eczema is a common and complex disease. Missing genetic hereditability and increasing prevalence in industrializing nations point toward an environmental driver. We investigated the temporal association of weather and pollution parameters with eczema severity. This cross-sectional clinical study was performed between May 2018 and March 2020 and is part of the Tower Hamlets Eczema…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations The @EdelOToole lab models on how #weather and #pollution effect #eczema show #ozone is a problem https://t.co/fgal0pA2be #dermtwitter https://t.co/FujA6rpxYR
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Mashup Score: 0Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis - 3 year(s) ago
Psoriasis and atopic dermatitis are chronic inflammatory skin diseases characterized by keratinocyte (KC) hyperproliferation and epidermal acanthosis (hyperplasia). The milieu of disease-associated cytokines and soluble factors is considered a mitogenic factor; however, pinpointing the exact mitogens in this complex microenvironment is challenging. We employed organotypic human epidermal…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations What makes scale in #eczema and #psoriasis? Uncovering the signaling pathways responsible. https://t.co/cMGO6WKQXb #dermtwitter https://t.co/N9JcVDc5pz
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Mashup Score: 2Allogeneic ABCB5+ Mesenchymal Stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial - 3 year(s) ago
A significant number of chronic venous ulcers (CVUs) fail to heal despite guideline-conform standards of care. Skin-derived ABCB5+ mesenchymal stem cells can dampen the sustained IL-1β‒driven inflammation present in chronic wounds. On the basis of their wound healing‒facilitating effects in a mouse CVU model and an autologous first-in-human study, ABCB5+ mesenchymal stem cells have emerged as a…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations Mesenchymal #stemcells may be the new way to heal chronic venous ulcers https://t.co/DKl6ihjr8n #medderm #dermtwitter https://t.co/pvb2Tk6BGZ
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Mashup Score: 0Hyperactivated Mast Cells Pathogenesis Hypothesis for COVID-19 Cutaneous Manifestations - 3 year(s) ago
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes mucocutaneous manifestations, including maculopapular eruptions, urticaria, and unusual acral vasculopathic rashes (pseudochilblains, pernio-like lesions) referred to as COVID toe. Cutaneous manifestations can occur in asymptomatic individuals, sometimes preceding COVID-19 symptoms, concurrent with COVID-19, or commonly after…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations A proposed role for #mastcells in cutanous maifestations of #COVID-19 #dermtwitter #dermscience https://t.co/S4ScMBK4WD
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Mashup Score: 0Cytokine Profiling in Low- and High-Density Small Extracellular Vesicles from Epidermoid Carcinoma Cells - 3 year(s) ago
Exosomes or small extracellular vesicles (sEVs) are membrane-bound nanoparticles that carry various macromolecules and act as autocrine and paracrine signaling messengers. In this study, sEVs from epidermoid carcinoma cells influenced by membrane presentation of the glycoprotein desmoglein 2 and its palmitoylation state were investigated. In this study, sEVs were isolated by sequential…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations #cytokine profiling helps uncover mechanisms of immune evasion in #squamouscellcarcinoma https://t.co/DHcfzLn1tA #dermtwitter #dermscience https://t.co/XVVccAcOyx
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Mashup Score: 0Use of Indoor Tanning Diagnosis Codes in Claims Data - 3 year(s) ago
The International Classification of Diseases: 10th Revision (effective from October 2015) included indoor tanning diagnosis codes for the first time. The majority of data on indoor tanning is self-reported. We used a large claims dataset to investigate the patients and settings in which indoor tanning International Classification of Diseases: 10th Revision codes are being used. We included…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations @MWehnerMD @shgiordano et al suggest ICD-10 code #claimsdata can help #dermatologists understand the impact of #indoortanning on our patients https://t.co/f1ZtYtwAdy #dermtwitter #dermscience https://t.co/R3TQP1VHUQ
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Mashup Score: 1Unsupervised Phenotype-Based Clustering of Clinicopathologic Features in Cutaneous Melanoma - 3 year(s) ago
Pathogenic phenotypes in cutaneous melanoma have been vastly cataloged, although these classifications lack concordance and are confined to either morphological or molecular contexts. In this study, we perform unsupervised k-medoids clustering as a machine learning technique of 2,978 primary cutaneous melanomas at Mass General Brigham and apply this information to elucidate computer-defined…
Source: JID InnovationsCategories: Dermatology, Latest HeadlinesTweet-
#JIDInnovations Unsupervised #machinelearning suggests new insights about #melanoma https://t.co/40XX85Rg4y https://t.co/iSOo5G5usG
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#JIDInnovations As we approach the 20th anniversary of 9/11, @charlesBHallPhD and collegues investigated the latency period of #melanoma among exposed rescue/recovery workers and found a 34% increased risk https://t.co/nCVQuMr69j #dermtwitter