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    Cytoreductive cystectomy appears to have survival advantages as a part of multimodal approach for well-selected patients with bladder cancer. Patient with clinical lymph node metastases might benefit from surgical consolidation after achieving a measurable response to chemotherapy. The exact role of cytoreductive/consolidative cystectomy is yet to be determined in well-designed prospective trials.

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    Ureteral obstruction causes an acute inflammatory response mediated by T cells, Th1 cells, and M1 macrophages; with prolonged obstruction, the ureter undergoes fibrotic changes.Ureteral obstruction might impair ureteral functionality in the long term due to fibrosis.The contralateral ureter might be affected.

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    Genomic profiling represents the first clinical practice–ready tool for precision oncology in metastatic prostate cancer. Here we outline current testing considerations and gray zones regarding how best to apply genomic testing in the clinic. The lessons we learn today will continue to shape how we integrate evolving biology and future technologies into practice.

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    Our study evaluated changes in microbiome after circumcision in children. The findings highlighted by our analysis show a remarkable change in overall bacterial and fungal compositions, and a shift from anaerobic to aerobic bacteria and skin flora. The reduction in bacterial and fungal bioburden seen in our study may correlate with a potential inflammatory cascade and oncogenic processes seen in…

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    • Characterization of Changes in Penile Microbiome Following Pediatric Circumcision #some4pefsurg #some4surgery #circumcision #microbiome https://t.co/v0oVaLn4UO

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    In multiple areas of urologic disease we are finally entering the era of precision medicine, personalizing management strategies based on an understanding of an individual patient’s biology rather than simply on a diagnosis. Application of these insights in clinical practice is typically achieved through biomarkers, indicators of disease or host status that are readily measurable in blood, urine,…

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    • RT @EurUrolFocus: Current Issue Editorial: Biomarkers in Urologic Oncology: So Much Progress, So Much Yet To Do https://t.co/lZ38RZcZjo…