With ageing, normal human tissues experience an expansion of somatic clones that carry cancer mutations1–7. However, whether such clonal expansion exists in the non-neoplastic intestine remains unknown. Here, using whole-exome sequencing data from 76 clonal human colon organoids, we identify a unique pattern of somatic mutagenesis in the inflamed epithelium of patients with ulcerative colitis….
Nature Reviews Genetics – In this Review, Coyle and King explore how genomic and functional data from diverse species are providing new insights into the…
Nature Neuroscience – Time-resolved electron microscopy reveals that intersectin-1 and endophilin A1 condensates hold replacement synaptic vesicles close to release sites. Without this, replacement…
Nature Reviews Clinical Oncology – In these Evidence-Based Guidelines, a multidisciplinary panel of experts from the European Hematology Association and the European Myeloma Network provide…
Nature Reviews Neurology – A voice-synthesis neuroprosthesis based on a brain–computer interface has restored instantaneous, natural-sounding speech to a man with amyotrophic lateral sclerosis.
Nature Communications – Glycolytic enzymes form self-organized traveling waves at the cell membrane/cortex, boosting local ATP production and cell movement. Cancer cells with intense waves…
Nature Biotechnology – Colorectal cancer is discriminated by measuring cell-free RNA methylation in plasma.
npj Aging – Psilocybin treatment extends cellular lifespan and improves survival of aged mice
Nature Neuroscience – Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral…
Nature Medicine – Campaigners want ultra-processed foods to be better defined and regulated. But does the evidence support strong policy changes?
Nature – A computational model called Centaur, developed by fine-tuning a language model on a huge dataset called Psych-101, can predict and simulate human nature…
