SHP2: when cardiology meets hematology | Blood | American Society of Hematology
In this issue of Blood, Bellio et al identified a causal link between a platelet signaling defect and bleeding in patients with Noonan syndrome (NS) who have activating mutations of Src homology 2 (SH2) domain-containing phosphatase 2 (SHP2).1 NS is a developmental disorder affecting 1 in every…