Serotonin transporter (SERT) inhibits CD8 T cell antitumor immunity by depleting intratumoral serotonin. SERT-blocking selective serotonin reuptake inhibitor (SSRI) antidepressants enhance CD8 T cell antitumor immunity and synergize with anti-PD-1, highlighting SSRIs as potential cancer immunotherapeutics.
The emergence of resistance mutations in the SARS-CoV-2 spike (S) protein presents a challenge for monoclonal antibody treatments like sotrovimab. Understanding the structural, dynamics, and…
Ben-Simon et al. present a comprehensive toolkit of transgenic lines and enhancer AAVs for targeted study of mammalian cortical cell types, facilitating understanding of brain…
Based on the principle of refractive index matching, highly transparent upconversion contact lenses (UCLs) with a high concentration of upconversion nanoparticles (UCNPs) were developed. These…
Sirenko et al. profile IDH1/2-mutated AML patients across disease stages (diagnosis, remission, and relapse) and treatments (targeted IDH inhibitors, chemotherapy, and hypomethylating agents). They delineate…
Over four decades, gene therapy for blood cell diseases—IEI, leukodystrophies, lysosomal storage disorders, and hemoglobinopathies—has advanced through iterative improvements in vector technology, stem cell processing,…
Stress often causes insomnia, yet certain stressors, including illness and psychosocial events, can induce sleep. Yu et al. propose that post-stress sleep contributes to resilience…
Cao et al. demonstrate excitatory neuronal tropism of the AAV capsid AAV-MG1.2 that was initially proposed for targeting microglia in the mouse brain. AAV-MG1.2 shows…
Kussick et al. generated epigenomic datasets from rodent and macaque spinal cords, identified enhancer elements to drive gene expression in spinal motor neurons, extensively characterized…
Velazquez-Rivera et al. have developed and validated a set of new BEC-enhancer AAV vectors that allow for selective genetic labeling of, and access to, brain…
He et al. demonstrate a “monkey-first” approach to cell-type-specific reagent development. They use machine learning to identify enhancers from rhesus monkey dorsolateral prefrontal cortex (DLPFC)…
