Colucci et al. review the defining features of senescence in cancer, its roles in tumor cells, the stroma, and the immune system, and its context-dependent effects as either tumor-promoting or tumor-suppressing mechanism. They also discuss current and emerging therapeutic strategies to induce or eliminate senescent cells in cancer and AI-driven approaches to detect and characterize them.
Pharmacological activation of the stimulator of interferon genes (STING) pathway triggers inflammatory innate immune responses to potentially reinvigorate tumor immunogenicity. Recent work by Dang et…
Neuro–immune crosstalk regulates inflammation and host metabolism via neural modulation of innate lymphoid cells (ILCs). Significant knowledge gaps remain regarding the signaling pathways, regulators, and…
CD8+ T cells, traditionally recognized for their cytotoxic role in eliminating infections and malignancies, are now known to exhibit significant functional heterogeneity, as revealed by…
A natural variation in QT12, a negative regulator of field thermotolerance controlled by upstream NF-Y transcription factors, leads to its insensitive response to high temperature,…
Flaherty et al. demonstrate that the catalytic efficiency of METTL16 regulates expression of MAT2A to determine the intracellular SAM setpoint. Their data indicate that this…
Neuroinflammation is central to Alzheimer’s disease pathogenesis. Stephenson et al. establish that neutral lipid accumulation is necessary for microglial activation and that microglia expressing an…
tRNA modifications functionally interact with m6A to regulate mRNA decay.
How high stand density and shade regulate cambial activity and wood formation in perennial trees remains unclear. Wei et al. demonstrate that, in Populus, the…
Nahiyera et al. uncover the distinct Sca1pos neutrophils enriched in murine liver under steady-state condition, which increase during pathological conditions. Characterization reveals these cells as…
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