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Sealing the Threat: Life-Saving Percutaneous Device Closure of Rare Left Ventricular Pseudoaneurysm Following Myocardial Infarction:
AbstractBackgroundLeft ventricular pseudoaneurysm (LVPA) is a rare yet potentially life-threatening complication following myocardial infarction or cardiac surgery. Although surgical repair has tra…
The Global Syndemic of Modifiable Cardiovascular Risk Factors Projected From 2025 to 2050:
AbstractBackgroundCardiovascular diseases (CVDs) are the leading cause of global mortality. Understanding epidemiologic trends in the modifiable risk factors driving CVDs is essential in designing …
NLRP3 Inflammasome Inhibition by the Novel Bispecific Antibody InflamAb Attenuates Atherosclerosis in Apolipoprotein E–Deficient Mice:
Highlights •We developed a novel bispecific antibody, InflamAb, designed to target the IL-1R1 for cell entrance and inhibit the intracellular NLRP3 inflammasome.•InflamAb potently inhibits NLRP3…
Pulsed-Field vs Thermal Catheter Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy:
AbstractBackgroundPulsed-field ablation (PFA) may be beneficial for the treatment of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).ObjectivesThe goal of this study was…
Established and Emerging Fluorine-18–Labeled Cardiac PET Radiotracers:
AbstractPositron emission tomography (PET)/computed tomography is a major imaging strategy for cardiovascular disease characterization. Whereas multiple radioisotopes can be used for PET imaging of…
Randomized Comparison of Fractional Flow Reserve and Instantaneous Wave Free Ratio in Serial Disease:
AbstractBackgroundFractional flow reserve (FFR) and the instantaneous wave-free ratio (iFR) identify arteries that benefit from percutaneous coronary intervention (PCI). FFR or iFR gradients on pul…
Vasoplegia Syndrome After Cardiac Surgery: Insights Into Mechanisms and Treatment
AbstractVasoplegia syndrome is a specific form of vasodilatory shock encountered in patients who undergo cardiac surgery, most commonly with cardiopulmonary bypass, which is characterized by…
Changes in Frailty and Cardiometabolic Disease: Evidence From a Longitudinal Cohort Study and Genetic Analysis
AbstractBackgroundCardiometabolic diseases (CMD) include coronary heart disease, stroke, and diabetes. Patients who have ≥2 CMD are defined as cardiometabolic multimorbidity (CMM). CMD and CMM have…
Percutaneous Occlusion of a Post-Surgical Saphenous Vein Graft Pseudoaneurysm Utilizing Neurological Microcoils and Embolic Agents:
AbstractBackgroundPostsurgical pseudoaneurysms at the anastomosis of saphenous vein grafts are uncommon and may result in catastrophic complications owing to their fragility and the risk of…
The Relevance of the Type of Ventricular Arrhythmia in Titin-Related Dilated Cardiomyopathy: A Multicenter Study
AbstractBackgroundTruncating titin variants (TTNtvs) are the most prevalent cause of inherited dilated cardiomyopathy. Occurrence of different ventricular arrhythmia (VA) subtypes, including premat…