The immune and sensory nervous systems work in concert to defend against threats and maintain homeostasis. In this issue of Immunity, Ugolini and colleagues review how immune signals activate specialized sensory neuron subtypes, triggering the release of neuropeptides, neurokines, and mediators that enable precise immune modulation and the regulation of tissue homeostasis.
The CCR5delta32 deletion arose on a pre-existing haplotype of 84 variants over 6,700 years ago in the Western Steppe. Positive selection drove it to high…
Gramatica et al. identify EZH2 overexpression as a mechanism of CTL resistance in HIV-infected CD4+ T cells. Inhibition of EZH2 with tazemetostat enhances MHC class I expression,…
Butyrophilin (BTN) receptor complexes sense phosphoantigens (pAgs) and activate Vγ9Vδ2 T cells, but the underlying mechanism remains unclear. Zhu et al. demonstrate that pAgs induce inside-out stabilization…
Dias et al. show that cross-reactive anti-dengue virus antibodies in pre-infection plasma that mediate complement-dependent virolysis of Zika virus correlate with protection from subsequent severe dengue…
Single-cell sequencing technologies have revealed the transcriptional diversity of microglia, the brain-resident macrophage population. In this issue, Stevens and colleagues discuss how microglia adapt to…
Sambaturu et al. show that SIV proviral DNA exists in both short- and long-lived CD4+ T cells, which harbor different genetically diverged virus populations. Thus, when CD4+…
To combat snake bites from diverse species, this work identifies broadly neutralizing antibodies from a donor hyperimmune to snake venom, and it demonstrates that a…
Arekar et al. demonstrate that the hepatic hormone hepcidin is essential for resistance to disseminated candidiasis. Hepcidin deficiency and associated iron overload result in inexorable fungal…
Li et al. report a telomere-to-telomere gap-free genome assembly for Tartary buckwheat and construct a phenotypically rich mutation library. They identified a large number of EMS-induced…
