Researchers at the University of Toronto have identified a key protein that supports the growth of many colorectal cancers. The study, which will be published December 27 in the Journal of Cell Biology, reveals that a protein called Importin-11 transports the cancer-causing protein βcatenin into the nucleus of colon cancer cells, where it can drive cell proliferation. Inhibiting this transport…
A DNN model reveals how sex-specific steroid variations influence aging, offering fresh insights into biological age prediction.
Nature Neuroscience – Through circuit dissection in juvenile, adolescent and adult mice, Klune, Goodpaster and colleagues reveal multiple developmental switches in mPFC–NAc and mPFC–BLA…
Nature Communications – The oncogenic splicing factor TRA2β is reported to be upregulated in human cancers partly by increased TRA2β poison exon (PE) skipping. Here…
Humanities and Social Sciences Communications – Cognitive neuroscience approach to explore the impact of wind turbine noise on various mental functions
npj Regenerative Medicine – Pharmacological or genetic inhibition of LTCC promotes cardiomyocyte proliferation through inhibition of calcineurin activity
Nature Neuroscience – Sehgal et al. show that branch-specific dendritic plasticity mechanisms in the retrosplenial cortex link memories acquired close in time such that, unlike…
Hyperammonemia induces liver injury, which can be prevented by inhibiting the Toll-like receptor 4 and RIPK1 pathway.
El Niño-Southern Oscillation (ENSO) impacts on infectious disease outbreaks may last multiple years via lagged nonlinear effects on population immunity Lagged immune response may cause…
From hot dogs and potato chips to chicken nuggets and sugary sodas, Americans are eating more ultra-processed foods (UPFs) than ever. Researchers estimate that up…
A trial at English secondary schools of alternative food labeling—which displayed the number of minutes of physical activity needed to burn off calories—reduced the purchase…
