Tumor-associated macrophages (TAMs) are key players in tumor progression, yet their role in this process remains only partially understood. In this issue of Cancer Cell, Sheban et al. demonstrate that zinc finger E-box-binding homeobox 2 (ZEB2) acts as a master regulator that reprograms TAMs toward a pro-tumor phenotype and that therapeutic targeting of ZEB2 exhibits anti-tumor activity.
Through integrative analyses of single-cell spatial multi-omics datasets, Liu et al. identify four distinct spatial subtypes of cancer-associated fibroblasts, conserved across cancer types and independent of…
Tumor-associated macrophages (TAMs) are key players in tumor progression, yet their role in this process remains only partially understood. In this issue of Cancer Cell,…
The Krebs cycle intermediates itaconate, succinate, and fumarate act as immunometabolites to regulate macrophage immune responses. This review highlights how these metabolites influence cytokine production…
Roughly 200 more employees at the National Institutes of Health will be laid off, reportedly to balance out recent rehires.
The National Institutes of Health (NIH) has laid off 250 more employees, with this round of cuts hitting 50 workers at the National Cancer Institute…
Targeted grant terminations have affected 694 National Institutes of Health (NIH) grants, resulting in $1.81 billion in terminated grant funding, according to a research letter…
Francis Collins: The Trump administration is “basically taking ‘move fast and break things’ and applying it to our nation’s medical research enterprise.”
A flu researcher the Trump administration elevated to power will now benefit from a massive funding award.
In a roughly five-week period this year, the U.S. National Institutes of Health terminated $1.81 billion in medical research funding, according to a new analysis.
NIH staff and allies hold weekly vigils in Bethesda, protesting Trump-era cuts, layoffs, and what they call an assault on public health and scientific integrity.
