Recent advances in therapeutic cancer vaccines
Nature Reviews Cancer – Cancer prevention vaccines have reduced cancer-related mortalities, yet therapeutic cancer vaccine development and clinical translation continues to face challenges. Here,…
Related Articles
Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment
Nature Communications – The tumor microenvironment influences the metabolic behavior of cancer cells. Here, using Dual Ribosome Profiling, the authors uncover a cancer-stromal cell interaction…
SARS-CoV-2 virus lacking the envelope and membrane open-reading frames as a vaccine platform
Nature Communications – In this study, the authors report a single cycle-replicating SARS-CoV-2 vaccine candidate virus (ΔEM) and show that it induces spike-specific IgA and…
Genomics reveals zoonotic and sustained human Mpox spread in West Africa
Nature – Genomics reveals zoonotic and sustained human Mpox spread in West Africa
On the conversational persuasiveness of GPT-4
Nature Human Behaviour – Salvi et al. find that GPT-4 outperforms humans in debates when given basic sociodemographic data. With personalization, GPT-4 had 81.2% higher…
Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes
Nature Communications – Existing clinical models cannot fully capture smoldering multiple myeloma (SMM) heterogeneity. Here, integration of 42 genetic alterations from 214 SMM patients using…
Targeting neutrophils for cancer therapy
Nature Reviews Drug Discovery – Neutrophils are abundant in the tumour microenvironment and often correlate with poor prognosis. This Review explores neutrophil subtypes — including…
Development and external validation of prediction algorithms to improve early diagnosis of cancer
Nature Communications – Diagnosing cancer early and accurately is key to improving patient outcome. Here, the authors have developed algorithms to estimate the chances of…
Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations
Nature Biomedical Engineering – Central nervous system lesions are reduced following focused ultrasound treatment in a mouse model.
Characteristics and treatment outcome in a prospective cohort of 639 advanced high-grade digestive neuroendocrine neoplasms (NET G3 and NEC). The NORDIC NEC 2 study
British Journal of Cancer – Characteristics and treatment outcome in a prospective cohort of 639 advanced high-grade digestive neuroendocrine neoplasms (NET G3 and NEC). The…
Dual mechanotherapy for the treatment of cardiac fibrosis
Nature Reviews Cardiology – Inhibition of mechanotransduction selectively in cardiac fibrolasts, especially when combined with inhibition of transforming growth factor-β signalling, triggers a…
