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Unique molecular assay (UMA): a next-generation sequencing targeted panel for efficient and comprehensive genomic profiling and risk stratification of multiple myeloma – PubMed
Multiple myeloma (MM) is characterized by genetic abnormalities in plasma cells, requiring precise genomic characterization for effective risk stratification and treatment. This study presents the…
Extramedullary Myeloma is Genomically Complex and Characterized by Near-Universal MAPK Pathway Alterations – PubMed
Extramedullary disease (EMD) is associated with an inferior prognosis and lower response rates to conventional multiple myeloma (MM)-directed therapies compared to MM without EMD. A…
Targeting high-risk multiple myeloma genotypes with optimized anti-CD70 CAR-T cells – PubMed
Despite the success of BCMA-targeting CAR-Ts in multiple myeloma, patients with high-risk cytogenetic features still relapse most quickly and are in urgent need of additional…
High-Deductible Health Plans and Out-of-Pocket Health Care Costs Among Younger Patients With Multiple Myeloma – PubMed
Compared with standard plan enrollees, OOP costs were higher for HDHP enrollees in the year after diagnosis, but HDHP enrollment was not associated with delays…
Outcomes of elderly patients with relapsed refractory multiple myeloma (RRMM) treated with teclistamab: a multicenter study from the U.S. Multiple Myeloma Immunotherapy Consortium – PubMed
Teclistamab, a BCMA-directed bispecific antibody, received regulatory approval for relapsed/refractory multiple myeloma (RRMM) based on the MajesTEC-1 study. Despite the fact that myeloma is primarily…
Myeloma Paper of the Day, May 10th, suggested by Robert Orlowski – OncoDaily
Myeloma Paper of the Day, May 10th, suggested by Robert Orlowski / Alexandre Eeckhoutte, Amina Joudat, Avital Tenenbaum, Brian A Walker, cancer, Damien
A multiomic analysis of Waldenström macroglobulinemia defines distinct disease subtypes – PubMed
We carried out a single-cell (sc) multiomic analysis on a series of MYD88 mutated Waldenström macroglobulinemia (WM) cases and identified two distinct subtypes of disease,…
Characterization of Belantamab Mafodotin-Induced Corneal Changes in Patients With Multiple Myeloma – PubMed
ClinicalTrials.gov Identifier: NCT04549363.
Myeloma Paper of the Day, May 8th, suggested by Robert Orlowski – OncoDaily
Myeloma Paper of the Day, May 8th, suggested by Robert Orlowski / Anjan Thakurta, Anshul Thakur, blood advances, cancer, Christopher C Butler, David A