T cell receptor proximity plays a critical role in MHC class II-dependent LAG-3 suppression of CD4+ T cells, which disrupts the association of receptor components CD3ε/Lck inside the cell. A bispecific antibody to both the TCR and LAG-3 maximizes T cell suppression in the context of autoimmune diseases.
The impact of neutrophil maturation in refractory tumors such as bone metastases remains underexplored. Shi et al. demonstrate that predominant immature neutrophils inhibit anti-tumor immunity…
Early antibiotic exposure disrupts the gut microbiota, impairing newborn antiviral immunity. Stevens et al. uncover that inosine, a metabolite produced by gut bacteria, restores the…
Humanized mouse models with transgenic expression of human myelopoiesis-supporting growth factors have enhanced human myeloid cell engraftment and improved the study of human innate immune…
Vagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia. Blocking the right cervical vagus nerve with various invasive or non-invasive approaches…
Feng et al. demonstrate the potent antitumor efficacy of MCB-294, a pan-KRAS inhibitor, and MCB-36, a derivative proteolysis-targeting chimera (PROTAC) degrader. MCB-294 engages both active…
Vagal dysfunction mediates the impact of tumor on liver metabolism, leading to cachexia. Blocking the right cervical vagus nerve with various invasive or non-invasive approaches…
Indigenous Orang Asli of Peninsular Malaysia raised concerns about the etiology, treatment, and transmission routes of the skin disorder tinea imbricata. Analyses of the associated…
This first-in-human use of an iPSC-derived CAR-NK therapy targeting CD19 and BCMA demonstrates safe and marked clinical responses in a patient with severe refractory systemic…
Maintenance Warning: The Cell Press website will be undergoing maintenance on Saturday, May 31st from 8am to 12pm US Eastern (4 hours). During this timeframe,…
