Zhu et al. identified Procr+ chondroprogenitors in the superficial layer of articular cartilage and meniscus, which are sensitive to mechanical stimulation and regenerate articular chondrocytes in a Piezo1-dependent manner, highlighting their therapeutic potential in treating cartilage defects and osteoarthritis.
Stress granules promote TDP-43 aggregation via intra-condensate demixing, a pathway triggered by its up-concentration and oxidation within condensates. Blocking this demixing pathway prevents TDP-43 aggregation,…
Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism…
Maintenance Warning: The Cell Press website will be undergoing maintenance on Saturday, May 31st from 8am to 12pm US Eastern (4 hours). During this timeframe,…
This study describes the development of an ingestible pill-based biosensor device, the pill for reactive oxygen species (ROS)-responsive inflammation monitoring (PRIM), that uses ROS-responsive polymers…
Precisely how diet regulates intestinal immunity and barrier function remains underexplored. Yu et al. identify a link between nutrient signals and host defense directed by…
Joo et al. demonstrate that constitutive mitotic ATR and Chk1 activity ensures faithful chromosome segregation. In mitosis, Chk1 phosphorylates and inhibits Myt1, a kinase that…
From the first use of chemotherapy in the 1960s to the first FDA-approved CAR T-cell therapy in 2017, the treatment of pediatric cancers has evolved…
In 1990, two seminal studies introduced a novel method, systematic evolution of ligands by exponential enrichment (SELEX), to discover and isolate aptamers: small, single-stranded oligonucleotides…
This study describes the development of an ingestible pill-based biosensor device, the pill for reactive oxygen species (ROS)-responsive inflammation monitoring (PRIM), that uses ROS-responsive polymers…
HGG Advances is an open access journal in its 5th year of publication covering the complete spectrum of human genetics and genomics research. HGG Advances…
