Preemptive Treatment of Herpes Simplex Virus Reactivation in Critically Ill Patients?—Not Based on Current Data

In a multicenter randomized clinical trial by Luyt et al1 published in this issue of JAMA Internal Medicine, twice-weekly screening for oropharyngeal reactivation of herpes simplex virus (HSV) followed by preemptive treatment with acyclovir during 14 days did not increase the number of…

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