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Catastrophic climate risks should be neither understated nor overstated | PNAS
Catastrophic climate risks should be neither understated nor overstated
SARS-CoV-2 nsp15 enhances viral virulence by subverting host antiviral defenses | PNAS
SARS-CoV-2 encodes numerous virulence factors, yet their precise mechanisms of action remain unknown. We provide evidence that the SARS-CoV-2 nonst…
Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty | PNAS
This study explores how researchers’ analytical choices affect the reliability of scientific findings. Most discussions of reliability problems in …
Representation of locomotive action affordances in human behavior, brains, and deep neural networks | PNAS
To decide how to move around the world, we must determine which locomotive actions (e.g., walking, swimming, or climbing) are afforded by the immed…
Take caution in using LLMs as human surrogates | PNAS
Recent studies suggest large language models (LLMs) can generate human-like responses, aligning with human behavior in economic experiments, survey…
Endogenous competition and the underrealized reproduction of infectious diseases | PNAS
Scientific inquiry about the transmissibility of infectious diseases is largely based on the basic reproduction number (R0) and its derivations. Th…
The analgesic paracetamol metabolite AM404 acts peripherally to directly inhibit sodium channels | PNAS
Paracetamol has been used for decades to relieve mild-to-moderate pain. Its analgesic effect is mainly attributed to its metabolite, AM404, acting …
A proteomic signature of healthspan | PNAS
The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability. Despite s…
Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons | PNAS
Periodontitis, a prevalent chronic inflammatory disease, profoundly impacts both quality of life and overall health. Clinical studies have suggeste…
Multiple sclerosis and gut microbiota: Lachnospiraceae from the ileum of MS twins trigger MS-like disease in germfree transgenic mice—An unbiased functional study | PNAS
We developed a two-tiered strategy aiming to identify gut bacteria functionally linked to the development of multiple sclerosis (MS). First, we com…