Lin et al. and Lambo et al. report in-depth therapeutic screening and genomic profiling, respectively, of two types of aggressive paediatric central nervous system tumours, and both groups identify vulnerabilities of these tumours that might be exploited therapeutically.
Nature Reviews Cancer – ALK genetic alterations drive various malignancies through aberrant tyrosine kinase activation, promoting oncogenic cell growth and survival. Here, Voena et al.…
Nature Reviews Cancer – Although sometimes overlooked, storytelling is a powerful tool for communicating scientific research. In this World View, Julia Bauman outlines what is…
Nature Reviews Cancer – Fibroinflammation, a highly integrated fibrogenic and inflammatory response, is activated in response to tissue perturbation and thus contributes to tumour initiation,…
Nature Reviews Cancer – In this Review, Erez and colleagues examine the complex interactions among tumours, their microenvironment and the host, shaping a metabolic macroenvironment…
Nature Reviews Cancer – In this Tools of the Trade article, Jordan Lee describes the development and use of the Tumor Molecular Pathology (TMP) toolkit,…
Nature Reviews Cancer – ALK genetic alterations drive various malignancies through aberrant tyrosine kinase activation, promoting oncogenic cell growth and survival. Here, Voena et al.…
Nature Reviews Cancer – A recent study published in Nature finds that neuroendocrine small-cell lung cancer (SCLC) cells exhibit electrical activity that directly drives tumour…
Nature Reviews Cancer – ALK genetic alterations drive various malignancies through aberrant tyrosine kinase activation, promoting oncogenic cell growth and survival. Here, Voena et al.…
Nature Reviews Cancer – In this Comment, Ben-Aharon et al. advocate for the creation of designated OncoYoung programs to address the unique needs of individuals…
Nature Reviews Cancer – Genetic predisposition is the major known cause of cancer in children and adolescents. In this Review, Kratz highlights the genetic architecture…
