Fang et al.’s study elucidated the role of Piezo1 in regulating normal and postinjury CSC fates through SCD1-Wnt-β-catenin and the SCD1-mediated fatty acid desaturation process. The results provide novel insights into the mechanical factors regulating ISC fate and therapeutic strategies for related intestinal diseases.
(Cell Reports 22, 3277–3291; March 20, 2018)
Oligo-LiveFISH is an approach that can track diverse genomic loci at high spatial (20 nm) and temporal (50 ms) resolution and can work in diverse…
The quantification of physical properties of biological matter gives rise to novel ways of understanding functional mechanisms. One of the basic biophysical properties is the…
Nguyen et al. demonstrate that variation in inverted repeats within C. difficile’s flagellar switch impacts the phase-variable expression of flagellar genes, which contributes to the…
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination,…
CAR T cell therapy can cause cognitive impairment in mouse models with central nervous system (CNS) and non-CNS cancers by inducing persistent neuroinflammation, thereby disrupting…
Speak with a Cell Press editor about your stem cell research
Arginine availability and metabolism critically shape tumor-immune interactions. In this issue of Cancer Cell, Zhu et al. demonstrate that breast cancer-cell-derived arginine synthesized via ASS1 fuels…
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination,…
