Heat stress poses a serious threat to grain quality and yield in rice. Li et al. identified a natural variation in QT12, which is regulated by NF-Y transcription factors and enhances thermotolerance for grain quality and yield by maintaining endosperm storage substance homeostasis.
Using a 3D co-culture system of iPSC-derived neurons and glia, termed iAssembloids, combined with CRISPRi-based screening, Li et al. investigate the effect of glial cells on…
(Cell Reports 22, 3277–3291; March 20, 2018)
Oligo-LiveFISH is an approach that can track diverse genomic loci at high spatial (20 nm) and temporal (50 ms) resolution and can work in diverse…
The quantification of physical properties of biological matter gives rise to novel ways of understanding functional mechanisms. One of the basic biophysical properties is the…
Nguyen et al. demonstrate that variation in inverted repeats within C. difficile’s flagellar switch impacts the phase-variable expression of flagellar genes, which contributes to the…
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination,…
CAR T cell therapy can cause cognitive impairment in mouse models with central nervous system (CNS) and non-CNS cancers by inducing persistent neuroinflammation, thereby disrupting…
Arginine availability and metabolism critically shape tumor-immune interactions. In this issue of Cancer Cell, Zhu et al. demonstrate that breast cancer-cell-derived arginine synthesized via ASS1 fuels…
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination,…
Pool et al. demonstrate PKA RIβ phase separation and evaluate how its condensates are dysregulated by two neurological disease mutations. Both Marbach-Schaaf neurodevelopmental syndrome variant…
