Benton et al. identify binders against common mutant KRAS neoantigens and create peptide-centric CAR-T cells (NeoCARs). NeoCARs demonstrate a robust anti-tumor response against cancer cells expressing mutant KRAS peptides by MHC, both in vitro and in vivo. Inducible cytokine release and TCR deletion further enhance the therapeutic index.
Merigliano et al. identified a non-canonical, “off-pore” role for nucleoporins in genome stability and in the spatial regulation of homologous recombination in multicellular eukaryotes. Nup98…
(Cell 166, 209–221; June 30, 2016)
Super-resolution microscopy (SRM) has transformed biological imaging by circumventing the diffraction limit of light and enabling the visualization of cellular structures and processes at the…
Wang et al. identify phosphoglycerate mutase (PGAM) as a negative regulator of pathogenic Th17 cell differentiation, contrary to other glycolytic enzymes. PGAM inhibition suppresses a…
Li et al. show that RORγt, the ILC3 master regulator, still plays a crucial role during the ILC3 activation phase. Although it is dispensable for…
Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism…
Zhuge et al. demonstrate that a toxoid vaccine platform based on phosphatidylcholine/sphingomyelin (PS)-hybridized lipids provides a broadly effective antivirulence vaccination strategy against diverse bacterial infections…
Almeida et al. use cryoelectron microscopy to determine three structures of the 160-kDa GPI-anchored protein CD109. A mechanism for the inhibition of proteases by CD109…
Fecal microbiota transplants (FMTs) may not always effectively restore small bowel microbiota due to regional differences in gut environments, potentially causing unintended effects on metabolism…
Recently, a copper-dependent form of cell death called cuproptosis has been described, distinct from apoptosis, ferroptosis, and other known pathways. Cuproptosis is defined by excessive…
