MT-125 is a small-molecule inhibitor of non-muscle myosin IIA and IIB that has multiple therapeutic effects on glioblastoma through the ability to increase reactive oxygen species in tumor cells.
To identify regulatory variants with plasticity in effect size, we performed interaction molecular quantitative trait loci (iQTL) mapping with cell-type abundance, age, sex, and smoking…
Human umbilical cord mesenchymal stem cells (UCMSCs) are a novel stem-cell source to treat osteoarthritis (OA). Here we investigated the therapeutic effects of UCMSCs injection…
The global spread of misinformation is undermining democracies worldwide. In this NeuroView, we explain how neuroscience can inform our basic understanding of what makes the…
Dang et al. report that group-3 medulloblastomas (MBs) show c-MYC-driven high DLAT expression. In these tumors, wild-type IDH1 epigenetically regulates c-MYC, and inhibiting IDH1 lowers…
CD36 is identified as the membrane receptor for cellular uptake of PROTACs and other eRo5/bRo5 molecules. A chemical endocytic medicinal chemistry strategy to enhance the…
Children with ASD exhibit gastrointestinal comorbidity symptoms and have a higher susceptibility to IBD. In this study, rodent models were used to demonstrate that maternal…
Transplants release extracellular vesicles (EVs) that disseminate donor antigens in lymphoid tissues, eliciting T and B cell allosensitization. Chen and Powell et al. demonstrate that…
Single-cell multiomic reconstruction of the human blood vessel organoid system allows for classifying and modeling disease and cell-type-specific states, demonstrating its potential for translational research.
The mechanisms governing the progression of precursor lesions to invasive lung adenocarcinoma (LUAD) remain poorly understood. In this issue of Cancer Cell, Zhu et al. map…
Kim et al. map gene regulatory networks of the developing mouse hypothalamus and prethalamus using single-cell multiomics, identifying regulators of regionalization and neurogenesis. They further…
