How chromosomes are positioned and folded within the nucleus has implications for gene regulation. In this Review, Kempfer and Pombo describe and evaluate methods for studying chromosome architecture and outline the insights they are providing about nuclear organization.
Super Agers is a detailed guide to a revolution transforming human longevity. This is a breakthrough moment in the history of human health care. Th…
Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches…
BackgroundCurrent guidelines suggest engaging in a minimum of 150 minutes of moderate to vigorous physical activity (MVPA) each week to support overall health. However, the…
Current BMI-based measures of obesity can both underestimate and overestimate adiposity and provide inadequate information about health at the individual level, which undermines medically-sound approaches…
Nature Medicine – A meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors, such as laboratory tests and baseline diagnoses, had superior…
Objectives Dedicated studies aimed at investigating the relationship between walking pace and arrhythmia are limited. This study assessed associations between self-reported and accelerometer measured walking…
This population-based cohort study examines the association of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors with the risk of Alzheimer disease and related dementias…
Scientists achieved “a milestone” by charting the activity and structure of 200,000 cells in a mouse brain and their 523 million connections.
Nature Medicine – A meta-prediction framework integrating polygenic risk scores spanning multiple conditions and nongenetic factors, such as laboratory tests and baseline diagnoses, had superior…
Nature – Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but…
