With a staggering amount of waste, as documented in the recent JAMA study, a key question is whether our health care system can produce the same or better outcomes for less money—in other words, can it become more productive or efficient? Until recently, the answer seemed to be “no.” But things may…
This JAMA Insights explores factor V Leiden, an inherited thrombophilia, and its association with venous and arterial thrombosis, how it affects pregnancy outcomes, and testing.
A man in his early 50s presented with recurrent episodes of cough, palpitations, shortness of breath, and exertional chest pain. What would you do next?
This prespecified subgroup analysis of the FAME 3 randomized clinical trial investigates the relative treatment effect of fractional flow reserve (FFR)–guided percutaneous coronary intervention vs…
This Viewpoint describes intrauterine and extrauterine auditory brain development and advocates for use of music therapy for preterm neonates in the neonatal intensive care unit…
This Review proposes a person-centered framework to improve independence and quality of life for people using supplemental oxygen and summarizes supplemental oxygen evidence and landscape…
This Special Communication introduces the updated Consolidated Standards of Reporting Trials (CONSORT) 2025 statement, which includes substantive and structural changes to account for recent methodological…
This Viewpoint explores the opportunities and risks posed by AI in the health care system through the lens of the National Academy of Medicine’s framework…
This Viewpoint explores potential justifications underlying the US Food and Drug Administration (FDA)’s rejection of methylenedioxymethamphetamine (MDMA) as a treatment for posttraumatic stress disorder, including…
This cohort study investigates the risk of and risk factors for poststroke epilepsy at a young age and validates current risk scores for poststroke epilepsy…
This prespecified subgroup analysis of the FAME 3 randomized clinical trial investigates the relative treatment effect of fractional flow reserve (FFR)–guided percutaneous coronary intervention vs…
