Long-lived cytokinetic bridges coordinate sister-cell elimination in mouse embryos
Here, Vasilev et al show that abscission, the final step of cell division, is delayed in the early mouse embryo, leaving sister cells connected by a stable cytoplasmic bridge throughout most of interphase. This sister-cell connection enables the sharing of apoptotic mediators and promotes the death of cells whose sisters have committed to apoptosis, such that apoptosis usually occurs in a pairwise manner in the early embryo.
