Li et al. use single nucleus sequencing of 217 large B cell lymphomas to identify microenvironment archetype profiles (LymphoMAPs), discovering their divergent biology and association with clinical characteristics and patient outcome following immunochemotherapy and CD19 CAR T cell therapy.
Wang et al. reconstructed the Trebouxiophyceae phylogeny and identified incomplete lineage sorting as the primary cause of gene tree heterogeneity. They underscored the pivotal role…
Multiple exposures to an evolving virus can drive antibody affinity maturation toward cross-reactivity. How viruses continue to evolve despite these broad antibodies is unclear. Maurer…
Indigenous Orang Asli of Peninsular Malaysia raised concerns about the etiology, treatment, and transmission routes of the skin disorder tinea imbricata. Analyses of the associated…
Satb1 has a key role in T cell development and differentiation. In this study, Köhne et al. showed that deletion of Satb1 in naive CD4+…
Ribosome-targeting drugs are widely used in basic research and medicine, yet the conservation of their binding residues in bacterial ribosomes remains unknown. Here, Ekemezie et…
Signals from environmental surfaces activate octopus chemotactile receptors, influencing behaviors such as maternal care and predation, thereby highlighting the role of microbiomes in shaping animal…
Modulation enhanced single-molecule localization microscopy (meSMLM), where emitters are sparsely activated with sequentially applied patterned illumination, increases the localization precision over single-molecule localization microscopy (SMLM).…
Manjila et al. identify the dorsal endopiriform nucleus (EPd) as a distinct cortical subplate structure enriched with oxytocin receptors (Oxtrs). EPd-Oxtr neurons connect bidirectionally with…
Cell Symposia: Precision genomics in human health
Colucci et al. review the defining features of senescence in cancer, its roles in tumor cells, the stroma, and the immune system, and its context-dependent…
