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The Lancet Gastroenterology and Hepatology: Homepage
Discover articles from The Lancet Gastroenterology & Hepatology, providing a clear, independent perspective about the clinical advances and practice-changing research shaping your specialty globally
Parental preconception BMI and risk of adverse birth outcomes in 8 million parent–child triads: a nationwide population-based cohort study in China
In this large, nationwide population-based cohort study, a preconception BMI in the category of underweight, overweight, or obesity in either or both parents was associated…
Healthy weight for the next generation’s health in China
Pre-pregnancy maternal obesity has long been recognised as a substantial contributor to adverse birth outcomes. However, the independent effect of pre-pregnancy paternal obesity, and its…
Total neoadjuvant treatment with short-course radiotherapy followed by sintilimab plus capecitabine–oxaliplatin versus short-course radiotherapy followed by capecitabine–oxaliplatin in patients with locally advanced rectal cancer (SPRING-01): a single-centre, open-label, phase 2, randomised controll
In patients with locally advanced rectal cancer, short-course radiotherapy combined with sintilimab and capecitabine–oxaliplatin as a total neoadjuvant treatment significantly increased the pathological complete response…
Incretins and the cardiovascular system: bridging digestion with metabolism
The mechanisms driving the cardiovascular and renal benefits of therapies targeting intestinal hormones in type 2 diabetes are still not fully understood. We propose that…
Copenhagen Declaration: a transformative vision for global diabetes
Diabetes is a leading global health and economic challenge, affecting over 800 million people worldwide, with over 80% residing in low-income and middle-income countries (LMICs).1…
Underrepresentation of older adults in diabetes and kidney disease trials
Management of older adults with type 2 diabetes and chronic kidney disease is complex. These individuals often have multiple comorbidities, take several medications, and are…
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Editors at eClinicalMedicine, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy. A monthly…
The brain as a window into rheumatoid arthritis stratified medicine?
TNF inhibitors have transformed outcomes for many, but not all, people with rheumatoid arthritis. Their approval in the late 1990s was soon followed by extensive…
Disease-associated brain activation predicts clinical response to TNF inhibition in rheumatoid arthritis (PreCePra): a randomised, multicentre, double-blind, placebo-controlled phase 3 study
High disease-associated fMRI CNS pain activation might predict clinical response of patients with rheumatoid arthritis to TNF inhibitor treatment.