Incorporating high-risk individuals beyond smoking history into lung cancer screening in Hong Kong: a cost-effectiveness study
Lung cancer (LC) accounts for 26.4% of all cancer deaths in Hong Kong (HK). Lung cancer screening (LCS) with low-dose computed tomography (LDCT) can reduce LC mortality. The cost-effectiveness of LDCT screening in high-risk individuals based on smoking history has previously been investigated. However, nearly half of HK LC patients never smoke, indicating a different LC epidemiology compared to Western countries, where the majority of LC cases are associated with smoking. We conducted a cost-effectiveness analysis for LCS, utilising local data and expanding the target population to include not only high-risk individuals identified based on smoking history, but also those identified through other risk factors.
