IGF-1 Provides Protective Role in Arteriosclerotic Cerebral Small Vessel Disease | Hypertension
BACKGROUND: Hypertension and advanced age are risk factors for arteriosclerotic cerebral small vessel disease (cSVD), a common cause of vascular dementia in elderly individuals. Circulating IGF-1 (insulin-like growth factor 1) levels decrease with age and are linked to age-related cognitive impairment. This study assessed the relationship between serum IGF-1 and arteriosclerotic cSVD severity in patients and the therapeutic effects and underlying mechanisms of exogenous IGF-1 supplementation in a cSVD rat model. METHODS: Serum and magnetic resonance images were collected from healthy subjects (n=26) and patients with arteriosclerotic cSVD (n=86). Stroke-prone renovascular hypertensive rats were used as cSVD animal models and subjected to the Morris water maze test, magnetic resonance imaging, immunohistochemistry, and biochemical analysis. Human cerebral microvascular endothelial cell line was utilized to validate the underlying mechanisms in vitro. RESULTS: Serum IGF-1 concentration w
