How I use maintenance therapy in acute myeloid leukemia
Treatment for patients with acute myeloid leukemia (AML) is being transformed for some patients, as targeted agents increase complete remission rates and s
Treatment for patients with acute myeloid leukemia (AML) is being transformed for some patients, as targeted agents increase complete remission rates and s
Key PointsT-PLL and other T-cell lymphomas are sensitive to drugs that target autophagy, nuclear export, and IAPs.IAP inhibition induces an upregulation of
Key PointsFLT3 gene is essential for ITD-mutated LSCs to establish and propagate leukemia, but not for FLT3–wild-type LSCs.Normal human HSCs do not require
Key PointsDurvalumab plus lenalidomide has an acceptable safety profile with durable responses in refractory/advanced CTCL in a phase 1 study.Immune checkp
Key PointsRecombinant ADAMTS13 can supply ADAMTS13 more efficiently than plasma to patients with congenital thrombotic thrombocytopenic purpura.Therapeutic
Key PointsFavorable outcomes were observed with dose-dense induction and PET-driven consolidation, with 2-year PFS at 86.2% and OS at 93.2%.The interim PET
Key PointsGlobal DNA methylation analysis reveals significant DMRs comparing WM with IgM-MGUS and IgM gammopathies with controls across genomic regions.Epi
Transfusions are part of standard care in many areas across medicine and are the “bread and butter” of practice for many hematologists, yet high-quality ev
In this issue of Blood, Pohly and colleagues present data from systematic, high-throughput drug screens for T-cell prolymphocytic leukemia (T-PLL), demonst
Key Points. Clonal hematopoiesis is present in at least 14% of patients with WM.Patients with CH are more likely to progress from IgM MGUS or…
Key Points3D silk-based bone marrow niches and flow chambers direct the generation of compartmentalized erythropoietic niches.Spatiotemporal control of ex