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Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease
Why microglia stop reducing amyloid deposits from Alzheimer’s disease (AD) brains is unknown. Prakash, Manchanda, et al. show that microglia increase their lipid droplets and…
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B
Maternal immune activation during pregnancy is associated with neurodevelopmental disorders in offspring, yet how maternal-fetal interface perturbations influence prenatal fetal myeloid cells and induce neurodevelopmental…
Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells
Blidner et al. identify a glycosylation-dependent, galectin-driven circuit as a common mechanism that simultaneously induces immunosuppressive and pro-angiogenic functions in myeloid-derived suppressor cells, revealing therapeutic…
Heterozygosity for Crohn’s disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection
ATG16L1T300A is associated with Crohn’s disease and causes immune dysfunction in mouse models, yet a plurality of humans are heterozygous carriers. Yao, Rudensky, et al.…
Speaker articles: Cell Symposia: Towards sustainable agriculture: Genomics, bioengineering, and smart technologies
Cell Symposia: Towards sustainable agriculture: Genomics, bioengineering, and smart technologies
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease
The functional role of TMEM119, a homeostatic microglial marker, has not been fully elucidated under Alzheimer’s disease (AD) pathological conditions. Liu et al. demonstrate that…
You know my NAMs
The critical immunoregulatory function of the lung nerve- and airway-associated macrophages (NAMs) is increasingly becoming evident. In this issue of Immunity, Yeung et al. report…
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses
T helper (Th) 2 cells and group 2 innate lymphoid cells (ILC2s) express similar effector molecules in response to distinct signals—TCR engagement and interleukin-33, respectively.…
Conference Program – Cell Symposia: Precision genomics in human health
Cell Symposia: Precision genomics in human health