Genomics of host–microbiome interactions in humans
Nature Reviews Genetics – In this Review, Ferretti et al. discuss advances in our understanding of interactions between the human genome and the microbiome, including the effects of the microbiome…
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Nature Cancer – Ferber et al. present an autonomous artificial intelligence agent system for deployment of specialized medical oncology computational tools, validating their system across…
Multimodal assessment of sleep-wake perception in insomnia disorder
Scientific Reports – Multimodal assessment of sleep-wake perception in insomnia disorder
Clonal dominance: mutations in VEXAS syndrome take advantage of inflammation
Nature Reviews Rheumatology – VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is caused by somatic mutations in UBA1 arising in hematopoietic stem cells, resulting…
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males
The massive systemic release of cellular contents after hemorrhagic shock is gasdermin D dependent, an effect more prominent in females.
Explosive mpox outbreak in Sierra Leone overwhelms health systems
Rapid transmission through sexual networks raises fears of wider spread in the region
The gut microbiome connects nutrition and human health
Nature Reviews Gastroenterology & Hepatology – In this Review, Sanz and colleagues discuss how diet shapes the gut microbiome, the role of diet–microbiome interactions on…
HSV-1 Encephalitis Prevented by Treatment Targeting Viral Enzymes
A key viral mechanism that allows HSV-1 to evade the brain’s natural defenses has been uncovered and tested to identify new treatments.
Ecological and evolutionary consequences of changing seasonality
Climate change and other anthropogenic drivers alter seasonal regimes across freshwater, terrestrial, and marine biomes. Seasonal patterns affect ecological and evolutionary processes at different ecological…
Disrupting Mechanical Transmission by Titin Protein Precipitates Muscle Diseases
Findings suggest that slack titin molecules drive muscle disease, potentially through mechanisms shared with other mechanical proteins.
Cockatoos have learned to operate drinking fountains in Australia
The behavior—never before seen in birds—may be a developing cultural tradition among one population