Winter et al. synthesize recent advances in the understanding of spinal projecting neurons—a specialized population of brain neurons that extend axons into the spinal cord to regulate motor, sensory, and autonomic functions. The authors propose a conceptual framework for understanding brain-control of bodily functions.
A generative AI platform is developed for de novo antibiotic design, yielding lead compounds with selective antibacterial activity, distinct mechanisms of action, and in vivo…
Circulating tumor cells (CTCs) are cancer cells shed into the bloodstream. While their utility has been limited by challenges in rare cell capture, recent technological…
Recently, a large pool of antigens derived from viral and bacterial microorganisms showing molecular mimicry with tumour-cell-expressed antigens was identified. These antigens can be presented…
Loss of cellular identity across aging and disease is linked to a widespread “mesenchymal drift,” characterized by upregulation of mesenchymal genes and altered stromal cell…
Jiang et al. explore the regulation and biological functions of 5-methylcytosine in lung squamous cell carcinoma modifications. USP8-mediated NSUN4 K11-linked ubiquitination inhibits DHCR24 degradation. The…
Inner speech is robustly represented in the motor cortex and can be decoded in real time to restore communication to people with paralysis. Unintentional decoding…
Ghisoni et al. profile the immune landscape of 697 ovarian cancers (OCs), identifying four immune phenotypes linked to prognosis and treatment response. The study demonstrates…
Cabaj et al. find that the RNA-binding protein PUM1 regulates α-synuclein levels by binding two Pumilio recognition elements in the SNCA 3′ UTR in mice…
Chemokines are essential signals that coordinate immune responses, yet how they are organized in time and space to convey information remains incompletely understood. Xi et…
This resource encompasses 644 gut bacteriome profiles from 212 wild and zoo-housed bonobos with associated data on 104 host and exposome factors. Leveraging this resource,…
